QUINOLINE AND INDOLOPYRIDOQUINAZOLINE ALKALOIDS FROM VEPRIS LOUISII

Article abstract of DOI:10.1016/0031-9422(82)83109-9

The structures of two new 2-quinolone alkaloids from the stem bark of Vepris louisii, N-methylpreskimmianine <7,8-dimethoxy-3-(3-methylbut-2-enyl)-1-methyl-2-quinolone> and veprisine (7,8-dimethoxy-N-methylflindersine) have been deduced from their spectral data and confirmed by partial synthesis from known compounds.Two minor indolopyridoquinazoline alkaloids were also isolated and identified as the already known 1-hydroxyrutaecarpine and the hitherto unknown 7,8-dehydro derivative of 1-hydroxyrutaecarpine. - Key Word Index: Vepris louisii; Rutaceae; stem bark; alkaloids; 2-quinolones; veprisine; N-methylpreskimmianine; indolopyridoquinazoline; 1-hydroxyrutaecarpine; 7,8-dehydro-1-hydroxyrutaecarpine.