436091-31-5Relevant academic research and scientific papers
Barton esters for initiator-free radical cyclisation with heteroaromatic substitution
Coyle, Robert,Fahey, Karen,Aldabbagh, Fawaz
, p. 1672 - 1682 (2013/03/28)
S-(1-Oxido-2-pyridinyl)-1,1,3,3-tetramethylthiouronium hexafluorophosphate (HOTT) facilitates the first examples of efficient radical cyclisation with (hetero)aromatic substitution via Barton ester intermediates. Cyclopropyl and alkyl radicals allow acces
Preparation of 4-(azol-1-yl)butyric acids by the interaction of azoles with γ-butyrolactone
Alekseenko,Popkov
, p. 769 - 775 (2008/03/11)
The interaction of salts of imidazole, 1,2,4-triazole, benzimidazole, and 2-benzylbenzimidazole with γ-butyrolactone has been studied. Ab initio quantum-chemical calculations showed a preference for N-alkylation on interaction of azolates with γ-butyrolac
Octahydro-2H-pyrido[1,2-a] pyrazine compounds
-
, (2008/06/13)
A compound selected from those of formula (I): 1wherein: Ra represents linear or branched (C1-C6)alkylene, X represents a group selected from W1, —C(W1)—W2—, —W2—C(W1)—, —W2—C(W1)W2—, —W2-Ra- and —CH(OR1)— wherein W1, W2 and R1 are as defined in the description, when Y represents aryl or heteroaryl, or X represents a group selected from single bond, —C(W1)—, —W2—C(W1)—, —W2-Ra and —CH(OR1)— wherein W1, W2, Ra and R1 are as defined hereinbefore, when Y represents a fused bicyclic group, of formula: 2?wherein: A represents nitrogen-containing heterocycle having from 4 to 7 ring members that is unsaturated or partially saturated and optionally contains a second hetero atom, B represents phenyl ring optionally substituted by one or more groups as defined in the description, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, medicinal products containing the same are useful in the treatment of cognitive deficiencies.
