436091-59-7

Basic information

• Product Name: 4-BROMO-7-METHOXY-1H-INDOLE
• Synonyms: 4-BROMO-7-METHOXY-1H-INDOLE;1H-Indole, 4-broMo-7-Methoxy-;4-BroMo-7-Methoxyindole
• CAS NO: 436091-59-7
• Molecular Formula: C₉H₈BrNO
• Molecular Weight: 226.07
• Mol File: 436091-59-7.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 356.49°C at 760 mmHg
• Flash Point: 169.4°C
• Appearance: /
• Density: 1.591g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.667
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 15.56±0.30(Predicted)
• CAS DataBase Reference: 4-BROMO-7-METHOXY-1H-INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-7-METHOXY-1H-INDOLE(436091-59-7)
• EPA Substance Registry System: 4-BROMO-7-METHOXY-1H-INDOLE(436091-59-7)

Safety Data

• Hazardous Substances Data: 436091-59-7(Hazardous Substances Data)

Usage

General Description

4-Bromo-7-methoxy-1H-indole is a chemical compound with the molecular formula C9H8BrNO. It is a derivative of indole, a heterocyclic compound that is commonly found in various natural products and pharmaceuticals. This specific derivative contains a bromine atom at the 4-position and a methoxy group at the 7-position of the indole ring. The compound has been studied for its potential biological activities, including its use in the synthesis of pharmaceuticals and as a building block in organic chemistry. Additionally, it has been investigated for its potential role as a chemical intermediate in the synthesis of various compounds. However, further research is needed to fully understand and harness the potential uses of 4-bromo-7-methoxy-1H-indole in various applications.

InChI:InChI=1/C9H8BrNO/c1-12-8-3-2-7(10)6-4-5-11-9(6)8/h2-5,11H,1H3

Upstream product

• 85598-13-6 1-bromo-4-methoxy-2-methyl-3-nitro-benzene 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 108-39-4 3-methyl-phenol 
• 85598-12-5 4-bromo-3-methyl-2-nitro-phenol 
• 4920-77-8 3-methyl-2-nitrophenol 
• 33696-00-3 4-bromo-1-methoxy-2-nitrobenzene 
• 1826-67-1 vinyl magnesium bromide 

Downstream Products

• 1094172-65-2 C₂₀H₂₁BrN₂O₄ 
• 1247915-41-8 4-bromo-7-methoxyindoline 
• 153276-71-2 7-methoxy-1H-indole-4-carboxylic acid 
• 153276-72-3 methyl 7-methoxy-1H-indole-4-carboxylate 
• 1400276-22-3 C₁₄H₈Br₂FNO 
• 1400275-73-1 dimethyl (pyrrolo[3,2,1-kl]phenoxazine-3,8-diylbis{1H-imidazole-5,2-diyl(2S)pyrrolidine-2,1-diyl[(1R)-2-oxo-1-phenylethane-2,1-diyl]})biscarbamate 
• 1400276-09-6 C₁₄H₈Br₂FNO 
• 1400276-07-4 C₁₅H₁₀Br₂FNO 
• 1400276-20-1 C₁₅H₁₀Br₂FNO 
• 1333378-11-2 C₄₁H₃₅BrN₈O₆S₂ 
• 1333378-12-3 C₃₁H₃₁N₇O₄S₂ 
• 1333378-30-5 C₃₆H₃₉N₇O₆S₂ 
• 1333378-21-4 C₂₉H₂₇N₃O₄S₂ 
• 1333378-20-3 C₁₈H₁₆BrNO₃S 

Relevant articles and documents

AURORA AND FLT3 KINASES MODULATORS

The invention provides a compound having the formula (1): and salts thereof; wherein: R1 is hydrogen or C1-2 alkyl; and R2, R3 and R4 are the same or different and each is selected from hydrogen, C1-2 alkyl, fluorine, chlorine, C1-2 alkoxy and trifluoromethyl, provided that no more than two of R2, R3 and R4 are other than hydrogen. Also provided are pharmaceutical compositions containing the compounds and their use in medicine, and in particular in the treatment of cancer.

TETRACYCLIC XANTHENE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES

The present invention relates to novel Tetracyclic Xanthene Derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, Y1, Y2, Z, Ra, Rb, R1a, R1b and R2 are as defined herein. The present invention also relates to compositions comprising at least one Tetracyclic Xanthene Derivative, and methods of using the Tetracyclic Xanthene Derivatives for treating or preventing HCV infection in a patient.

Synthetic studies on dragmacidin D: Synthesis and assembly of three fragments towards an advanced intermediate

We report herein the approach to the key advanced intermediate in the synthesis of the bioactive marine natural product dragmacidin D. By employing a modular synthesis strategy of three fragments (5, 7, and 8), the advanced intermediate 3 has been successfully synthesized in 2.5% yield over 15 steps by starting from nitrotoluene 20. The synthesis also involves sequential cross-coupling reactions, namely Sonogashira and Suzuki-Miyaura reactions, so that various analogues can be efficiently synthesized, which will allow the study of structure-activity relationships of dragmacidin D.