436091-59-7

Usage

Uses

Used in Pharmaceutical Synthesis:
4-Bromo-7-methoxy-1H-indole is used as a key intermediate in the pharmaceutical industry for the synthesis of various drugs. Its unique structure allows for the development of new compounds with potential therapeutic properties, contributing to the advancement of medicinal chemistry.
Used in Organic Chemistry:
In the field of organic chemistry, 4-bromo-7-methoxy-1H-indole serves as a versatile building block for the creation of complex organic molecules. Its presence in the synthesis process can lead to the formation of novel compounds with diverse applications, including materials science and specialty chemicals.
Used in Chemical Research:
4-Bromo-7-methoxy-1H-indole is utilized as a research compound in chemical laboratories to study its potential biological activities and explore its role in the synthesis of various compounds. Further research is necessary to fully understand its capabilities and maximize its potential in different applications.
While the specific uses of 4-bromo-7-methoxy-1H-indole in different industries are not explicitly mentioned in the provided materials, its potential applications in pharmaceutical synthesis, organic chemistry, and chemical research are inferred based on its properties and the general uses of indole derivatives. Continued investigation into its biological activities and chemical behavior will likely reveal additional uses and applications for 4-BROMO-7-METHOXY-1H-INDOLE.

InChI:InChI=1/C9H8BrNO/c1-12-8-3-2-7(10)6-4-5-11-9(6)8/h2-5,11H,1H3

Upstream product

• 85598-13-6 1-bromo-4-methoxy-2-methyl-3-nitro-benzene 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 33696-00-3 4-bromo-1-methoxy-2-nitrobenzene 
• 1826-67-1 vinyl magnesium bromide 
• 4920-77-8 3-methyl-2-nitrophenol 
• 85598-12-5 4-bromo-3-methyl-2-nitro-phenol 
• 108-39-4 3-methyl-phenol 

Downstream Products

• 1094172-65-2 C₂₀H₂₁BrN₂O₄ 
• 1247915-41-8 4-bromo-7-methoxyindoline 
• 153276-71-2 7-methoxy-1H-indole-4-carboxylic acid 
• 153276-72-3 methyl 7-methoxy-1H-indole-4-carboxylate 
• 1400276-22-3 C₁₄H₈Br₂FNO 
• 1400275-73-1 dimethyl (pyrrolo[3,2,1-kl]phenoxazine-3,8-diylbis{1H-imidazole-5,2-diyl(2S)pyrrolidine-2,1-diyl[(1R)-2-oxo-1-phenylethane-2,1-diyl]})biscarbamate 
• 1400276-09-6 C₁₄H₈Br₂FNO 
• 1400276-07-4 C₁₅H₁₀Br₂FNO 
• 1400276-20-1 C₁₅H₁₀Br₂FNO 
• 1333378-11-2 C₄₁H₃₅BrN₈O₆S₂ 
• 1333378-12-3 C₃₁H₃₁N₇O₄S₂ 
• 1333378-30-5 C₃₆H₃₉N₇O₆S₂ 
• 1333378-21-4 C₂₉H₂₇N₃O₄S₂ 
• 1333378-20-3 C₁₈H₁₆BrNO₃S 

Relevant academic research and scientific papers

AURORA AND FLT3 KINASES MODULATORS

The invention provides a compound having the formula (1): and salts thereof; wherein: R1 is hydrogen or C1-2 alkyl; and R2, R3 and R4 are the same or different and each is selected from hydrogen, C1-2 alkyl, fluorine, chlorine, C1-2 alkoxy and trifluoromethyl, provided that no more than two of R2, R3 and R4 are other than hydrogen. Also provided are pharmaceutical compositions containing the compounds and their use in medicine, and in particular in the treatment of cancer.

AURORA AND FLT3 KINASES MODULATORS

The invention provides a compound having the formula (1) useful as modulator of the activity of Aurora kinases and FLT3 kinases: and salts thereof; wherein: R1 is hydrogen or C1-2 alkyl; and R2, R3 and R4 are the same or different and each is selected from hydrogen, C1-2 alkyl, fluorine, chlorine, C1-2 alkoxy and trifluoromethyl, provided that no more than two of R2, R3 and R4 are other than hydrogen. Also provided are pharmaceutical compositions containing the compounds and their use in medicine, and in particular in the treatment of cancer

TETRACYCLIC XANTHENE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES

The present invention relates to novel Tetracyclic Xanthene Derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, Y1, Y2, Z, Ra, Rb, R1a, R1b and R2 are as defined herein. The present invention also relates to compositions comprising at least one Tetracyclic Xanthene Derivative, and methods of using the Tetracyclic Xanthene Derivatives for treating or preventing HCV infection in a patient.

TETRACYCLIC XANTHENE DERIVATIVES AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES

The present invention discloses tetracyclic xanthene derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, Y1, Y2, Z, Ra, Rb, R1a, R1b, and R2 are as defined herein. The present invention also discloses compositions comprising at least one tetracyclic xanthene derivative, and methods of using the tetracyclic xanthene derivatives for treating or preventing HCV infection in a patient.

Synthetic studies on dragmacidin D: Synthesis and assembly of three fragments towards an advanced intermediate

We report herein the approach to the key advanced intermediate in the synthesis of the bioactive marine natural product dragmacidin D. By employing a modular synthesis strategy of three fragments (5, 7, and 8), the advanced intermediate 3 has been successfully synthesized in 2.5% yield over 15 steps by starting from nitrotoluene 20. The synthesis also involves sequential cross-coupling reactions, namely Sonogashira and Suzuki-Miyaura reactions, so that various analogues can be efficiently synthesized, which will allow the study of structure-activity relationships of dragmacidin D.

INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

Compounds of formula (I): wherein R4, R6 and R7 are defined herein, are useful as inhibitors of HIV replication.

Synthetic studies on dragmacidin D: synthesis of the left-hand fragment

We report a synthesis of a left-hand fragment of bis(indole)-class marine alkaloid, dragmacidin D. The synthesis features Suzuki-Miyaura reaction for the coupling of imidazolyl boronic acid and (4-indolyl)vinyl bromide.

INDOLES AS 5-HT6 MODULATORS

The present invention relates to novel compounds of formula (I) wherein m, n, R0, R1, R2, R3 and R4 are as described herein, to pharmaceutical compositions comprising the compounds, to processes for t

3-Amino-1-arylpropyl indoles and aza-substituted indoles and uses thereof

The present invention provides compounds of the formula: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein p, Ar, R1, R2, R3, Ra, Rb, Rc, Rd and Re are defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.

Enantioselective synthesis of the aminoimidazole segment of dragmacidin D

A facile enantioselective synthesis of the 2-aminoimidazole side-chain of dragmacidin D has been developed, which involved the regio- and stereoselective opening of the chiral epoxide 9 by a diindolylcuprate reagent, followed by further steps to give 5-substituted N-(1H-imidazol-2-yl)acetamide 2.