436091-81-5 Usage
Uses
Used in Oncology:
CHEMBRDG-BB 5836592 is used as an anti-cancer agent for its potential to treat various types of cancer, such as breast cancer and colon cancer. It works by inhibiting the growth of cancer cells, making it a promising candidate for cancer therapy.
Used in Anti-Inflammatory Applications:
CHEMBRDG-BB 5836592 is used as an anti-inflammatory agent for its ability to reduce inflammation and alleviate symptoms of inflammatory diseases. Its potential therapeutic applications in this area are currently being researched, and it may hold promise as a treatment for inflammatory conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 436091-81-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,3,6,0,9 and 1 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 436091-81:
(8*4)+(7*3)+(6*6)+(5*0)+(4*9)+(3*1)+(2*8)+(1*1)=145
145 % 10 = 5
So 436091-81-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H7FN4O2/c10-7-3-1-6(2-4-7)9-11-13-14(12-9)5-8(15)16/h1-4H,5H2,(H,15,16)
436091-81-5Relevant academic research and scientific papers
Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators
Sharma, Swagat,Kozek, Krystian A.,Abney, Kristopher K.,Kumar, Sushil,Gautam, Nagsen,Alnouti, Yazen,David Weaver,Hopkins, Corey R.
, p. 791 - 796 (2019/02/06)
The present study describes the discovery and characterization of a series of 5-aryl-2H-tetrazol-3-ylacetamides as G protein-gated inwardly-rectifying potassium (GIRK) channels activators. Working from an initial hit discovered during a high-throughput screening campaign, we identified a tetrazole scaffold that shifts away from the previously reported urea-based scaffolds while remaining effective GIRK1/2 channel activators. In addition, we evaluated the compounds in Tier 1 DMPK assays and have identified a (3-methyl-1H-pyrazol-1-yl)tetrahydrothiophene-1,1-dioxide head group that imparts interesting and unexpected microsomal stability compared to previously-reported pyrazole head groups.
