50907-29-4

Upstream product

• 105-36-2 ethyl bromoacetate 
• 50907-21-6 5-(4-fluorophenyl)-1H-1,2,3,4-tetrazole 
• 1194-02-1 4-fluorobenzonitrile 

Downstream Products

• 76765-84-9 5-(4-fluorophenyl)-2H-tetrazol-2-ylacethydrazide 
• 76766-23-9 5-<5-(4-fluorophenyl)-2H-tetrazol-2-ylmethyl>-4-phenyl-s-triazol-3-thiol 
• 76766-26-2 5-<5-(4-fluorophenyl)-2H-tetrazol-2-ylmethyl>-4-(4-tolyl)-s-triazol-3-thiol 
• 76766-25-1 5-<5-(4-fluorophenyl)-2H-tetrazol-2-ylmethyl>-4-(3-tolyl)-s-triazol-3-thiol 
• 76766-24-0 5-<5-(4-fluorophenyl)-2H-tetrazol-2-ylmethyl>-4-(2-tolyl)-s-triazol-3-thiol 
• 76765-93-0 1-<5-(4-fluorophenyl)-2H-tetrazol-2-ylacetyl>-4-phenylthiosemicarbazide 
• 76766-29-5 5-<5-(4-fluorophenyl)-2H-tetrazol-2-ylmethyl>-4-(4-chlorophenyl)-s-triazol-3-thiol 
• 76766-27-3 5-<5-(4-fluorophenyl)-2H-tetrazol-2-ylmethyl>-4-(3,4-dimethylphenyl)-s-triazol-3-thiol 
• 76765-95-2 1-<5-(4-fluorophenyl)-2H-tetrazol-2-ylacetyl>-4-(3-tolyl)thiosemicarbazide 
• 76765-96-3 1-<5-(4-fluorophenyl)-2H-tetrazol-2-ylacetyl>-4-(4-tolyl)thiosemicarbazide 
• 76765-97-4 1-<5-(4-fluorophenyl)-2H-tetrazol-2-ylacetyl>-4-(3,4-dimethylphenyl)thiosemicarbazide 
• 76765-94-1 1-<5-(4-fluorophenyl)-2H-tetrazol-2-ylacetyl>-4-(2-tolyl)thiosemicarbazide 
• 76765-98-5 1-<5-(4-fluorophenyl)-2H-tetrazol-2-ylacetyl>-4-(4-chlorophenyl)thiosemicarbazide 
• 76766-28-4 5-<5-(4-fluorophenyl)-2H-tetrazol-2-ylmethyl>-4-(2-ethoxyphenyl)-s-triazol-3-thiol 

Relevant academic research and scientific papers

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators

The present study describes the discovery and characterization of a series of 5-aryl-2H-tetrazol-3-ylacetamides as G protein-gated inwardly-rectifying potassium (GIRK) channels activators. Working from an initial hit discovered during a high-throughput screening campaign, we identified a tetrazole scaffold that shifts away from the previously reported urea-based scaffolds while remaining effective GIRK1/2 channel activators. In addition, we evaluated the compounds in Tier 1 DMPK assays and have identified a (3-methyl-1H-pyrazol-1-yl)tetrahydrothiophene-1,1-dioxide head group that imparts interesting and unexpected microsomal stability compared to previously-reported pyrazole head groups.