130865-83-7

Basic information

• Product Name: Ethyl α-hydroxy-α-(trifluoromethyl)phenylacetate
• Synonyms: Ethyl α-hydroxy-α-(trifluoromethyl)phenylacetate
• CAS NO: 130865-83-7
• Molecular Weight: 248.202
• Mol File: 130865-83-7.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Ethyl α-hydroxy-α-(trifluoromethyl)phenylacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl α-hydroxy-α-(trifluoromethyl)phenylacetate(130865-83-7)
• EPA Substance Registry System: Ethyl α-hydroxy-α-(trifluoromethyl)phenylacetate(130865-83-7)

Safety Data

• Hazardous Substances Data: 130865-83-7(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 93923-55-8 3,3,3-trifluoro-2-hydroxy-2-phenyl-propionitrile 
• 13081-18-0 ethyl-3,3,3-trifluoropyruvate 
• 100-59-4 phenylmagnesium chloride 
• 434-45-7 2,2,2-Trifluoroacetophenone 
• 109-92-2 ethyl vinyl ether 
• 36750-88-6 1-phenyl-3,3,3-trifluoro-1,2-propanedione 
• 1603-79-8 phenylglyoxylic acid ethyl ester 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 71-43-2 benzene 
• 75-63-8 Bromotrifluoromethane 

Downstream Products

• 175401-23-7 Ethyl α-mesyloxy-α-(trifluoromethyl)phenylacetate 
• 55519-22-7 3,3,3-trifluoro-2-hydroxy-2-phenylpropanoic acid 
• 436097-14-2 [3-cyano-4-methyl-5-phenyl-5-(trifluoromethyl)-2(5H)-furanylidene]propanedinitrile 
• 90784-42-2 ethyl 3,3,3-trifluoro-2-phenylpropionate 
• 56539-85-6 α-(trifluoromethyl)-phenylacetic acid 
• 434-45-7 2,2,2-Trifluoroacetophenone 

Relevant articles and documents

Microwave synthesis with D - π - A structure of second-order non-linear optical chromophore method

The invention belongs to a synthesis method of an organic second-order nonlinear optical chromophore with a cyclic polyene structure compound as an electron bridge and especially relates to a second-order nonlinear optical chromophore which is synthesized by microwave heating, contains a high-performance electron donor (D) of an aldehyde group, a cyclic polyene structured electron bridge (pi) and a tricyano-dihydro furan (TCF) or trifluoro-substituted tricyano-dihydro furan (CF3-TCF) electron acceptor (A) and has a D-pi-A structure. The second-order nonlinear optical chromophore has a structure as shown in the specification. By a microwave heating method, the electron donor and the compound with the cyclic polyene structure undergo a chemical reaction in the presence of anhydrous ethanol and sodium ethoxide. Heat energy loss is reduced, reaction molecular collision probability is enhanced, reaction time is greatly shortened, reaction rate is increased, and reaction yield is raised.

Asymmetric 1,2-Perfluoroalkyl Migration: Easy Access to Enantioenriched α-Hydroxy-α-perfluoroalkyl Esters

This study has led to the development of a novel, highly efficient, 1,2-perfluoro-alkyl/-aryl migration process in reactions of hydrate of 1-perfluoro-alkyl/-aryl-1,2-diketones with alcohols, which are promoted by a Zn(II)/bisoxazoline and form α-perfluoro-alkyl/-aryl-substituted α-hydroxy esters. With (-)-8-phenylmenthol as the alcohol, the corresponding menthol esters are generated in high yields with excellent levels of diastereoselectivity. The mechanistic studies show that the benzilic ester-type rearrangement reaction takes place via an unusual 1,2-migration of electron-deficient trifluoromethyl group rather than the phenyl group. The overall process serves as a novel, efficient, and simple approach for the synthesis of highly enantioenriched, biologically relevant α-hydroxy-α-perfluoroalkyl carboxylic acid derivatives.

Superacid catalyzed hydroxyalkylation of aromatics with ethyl trifluoropyruvate: A new synthetic route to Mosher's acid analogs

A new superacid catalyzed Friedel-Crafts hydroxyalkylation of aromatics with ethyl trifluoropyruvate is described. The trifluoromethanesulfonic acid or gallium(III) trifluoromethane-sulfonate catalyzed reactions give α-hydroxy α-trifluoromethyl phenyl acetic acid ethyl ester and its derivatives (analogs of Mosher's acid) in good yields for both highly activated heteroaromatics and substituted benzenes.