4361-07-3

Usage

Uses

Used in Pharmaceutical Industry:
(2-methylpropylidene)propanedioic acid is used as a building block for the synthesis of various pharmaceuticals and organic compounds.
Used in Polymer and Plastics Industry:
(2-methylpropylidene)propanedioic acid is used as a monomer in the manufacturing of polymers, plastics, and resins.
Used in Food Industry:
(2-methylpropylidene)propanedioic acid is used in the food industry for various applications.
Safety Precautions:
It is important to handle (2-methylpropylidene)propanedioic acid with care and adhere to safety protocols due to its potential hazardous properties.

Upstream product

• 5652-68-6 diethyl 2-(2-methylpropylidene)malonate 
• 141-82-2 malonic acid 
• 78-84-2 isobutyraldehyde 

Relevant academic research and scientific papers

Ionic liquid as catalyst and reaction medium - A simple, efficient and green procedure for Knoevenagel condensation of aliphatic and aromatic carbonyl compounds using a task-specific basic ionic liquid

The basic ionic liquid 1-butyl-3-methylimidazolium hydroxide, [bmIm]OH, efficiently catalyzes Knoevenagel condensation without requirement of any organic solvent. A wide range of aliphatic and aromatic aldehydes and ketones easily undergo condensations with diethyl malonate, malononitrile, ethyl cyanoacetate, malonic acid and ethyl acetoacetate. The reactions proceed at room temperature and are very fast (10-30 min). However, the most significant feature of this methodology is the condensation of aliphatic aldehyde with diethyl malonate, which is not very easy to achieve by conventional reagents, and was not addressed adequately in literature providing a general and convenient procedure. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.

Inhibitors of Thermus thermophilus isopropylmalate dehydrogenase

In an attempt to use mechanism-based design for the discovery of inhibitors of the isopropylmalate dehydrogenase from T. thermophilus, we have prepared and studied a number of potential mimics for an intermediate in the oxidative decarboxylation of isopropyl malate, the enol or enolate of α-ketoisocaproate. Because hydroxamate and dicarboxylate enolate mimics are strong, uncompetitive inhibitors of the enzyme and vinyl fluoride enol mimics are weak, competitive inhibitors, it is suggested that the reaction involves the enolate. The uncompetitive inhibition by a number of anionic compounds suggests, in combination with previous studies in other laboratories, that they mimic the enolate product of the decarboxylation. An explanation for the potency of the inhibition of IMDH by these compounds is proposed based on the electrostatic interaction of product and cofactor.