436143-89-4

Upstream product

• 1209778-27-7 (5S,6S,E)-methyl 6-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]-5-hydroxyhept-2-enoate 
• 436143-85-0 (E)-(5S,6S)-6-((4R,5R)-2,2-Dimethyl-5-phenyl-[1,3]dioxolan-4-yl)-5-hydroxy-hept-2-enoic acid allyl ester 
• 436143-84-9 3-(2,2-dimethyl-5-phenyl-[1.3]dioxolan-4-yl)-1-[1,3]dithian-2-yl-butan-2-ol 
• 436143-90-7 5-[1,3]dithian-2-yl-3-methyl-1-phenylpentane-1,2,4-triol 
• 436143-91-8 (3S,4S)-4-((4R,5R)-2,2-Dimethyl-5-phenyl-[1,3]dioxolan-4-yl)-3-hydroxy-pentanal 
• 436143-83-8 2-methyl-7-phenyl-6,8-dioxabicyclo[3.2.1]octan-3-ol 

Downstream Products

• 436143-87-2 (R)-3-(3-Chloro-4-methoxy-phenyl)-2-[(E)-(5S,6S)-6-((4R,5R)-2,2-dimethyl-5-phenyl-[1,3]dioxolan-4-yl)-5-hydroxy-hept-2-enoylamino]-propionic acid 2,2,2-trichloro-ethyl ester 
• 1209778-29-9 C₂₉H₃₄ClNO₅ 
• 436143-88-3 2-(3-tert-butoxycarbonylamino-2-methyl-propionyloxy)-4-methyl-pentanoic acid 4-[2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-1-[1-(2,2-dimethyl-5-phenyl-[1,3]dioxolan-4-yl)-ethyl]-but-3-enyl ester 
• 196794-26-0 (E)-(3S,6R,10R,16S)-10-(3-Chloro-4-methoxy-benzyl)-16-((1R,2R,3R)-2,3-dihydroxy-1-methyl-3-phenyl-propyl)-3-isobutyl-6-methyl-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone 
• 124689-65-2 cryptophycin-1 

Relevant academic research and scientific papers

"Clicktophycin-52": A bioactive cryptophycin-52 triazole analogue

(Figure Presented) An endocycllc trans-amide linkage within the macrocyclic antitumor agent cryptophycin-52 was replaced by a 1,4-disubstituted 1H-1,2,3-triazole ring. Macrocyclisation of the trlazole analogue was accomplished by macrolactamizatlon as wel

Stereospecific synthesis of cryptophycin 1

Matrix presented A brief stereospecific synthesis of cryptophycin 1 is described in which (R)-mandelic acid serves as the sole source of asymmetry for unit A. The key step is a hetero-Diels-Alder cycloaddition.