436153-33-2

Upstream product

• 23511-69-5 N-(benzyloxycarbonyl)-2-oxo-azepane 
• 436153-24-1 7-(tert-butyl-dimethyl-silanyloxy)-2,3,4,5-tetrahydro-azepine-1-carboxylic acid benzyl ester 
• 436153-25-2 3-methylene-2-oxo-azepane-1-carboxylic acid benzyl ester 
• 436153-29-6 tert-Butyl-((E)-4-methyl-penta-2,4-dienyloxy)-diphenyl-silane 
• 501-53-1 benzyl chloroformate 
• 436153-31-0 (1S,6S)-1-(tert-Butyl-diphenyl-silanyloxymethyl)-3-methyl-7-oxo-8-aza-spiro[5.6]dodec-2-ene-8-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Asymmetric construction of the azaspiro[5.6]dodec-9-ene system in marine natural toxins

The asymmetric formation of azaspiro[5.6]dodec-9-ene system is described. The Diels-Alder reactions of an α-methylene caprolactam and diene in the presence of a Cu(II) and (S,S)-tBu-BOX complex afford the desired spirocyclic compounds with good exo-selectivity as well as excellent enantioselectivity. These exo-adducts would be applicable to the synthesis of marine natural toxins including the corresponding cyclic imine moiety.