23511-69-5Relevant articles and documents
2 - Trifluoromethyl - 1 - benzyloxycarbonyl - 1 - nitrogen heterocyclic alkane preparation method
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Paragraph 0018-0021, (2018/02/04)
The invention discloses a preparation method of 2-trifluoromethyl-1-carbobenzoxy-1-aza-cyclane, and mainly solves the problems that the step of the preparation of alpha-position trifluoromethyl aza-cyclane is long, the yield is low, and the like. The meth
Asymmetric construction of the azaspiro[5.6]dodec-9-ene system in marine natural toxins
Ishihara, Jun,Horie, Mariko,Shimada, Yoshikatsu,Tojo, Shingo,Murai, Akio
, p. 403 - 406 (2007/10/03)
The asymmetric formation of azaspiro[5.6]dodec-9-ene system is described. The Diels-Alder reactions of an α-methylene caprolactam and diene in the presence of a Cu(II) and (S,S)-tBu-BOX complex afford the desired spirocyclic compounds with good exo-selectivity as well as excellent enantioselectivity. These exo-adducts would be applicable to the synthesis of marine natural toxins including the corresponding cyclic imine moiety.