436804-26-1Relevant academic research and scientific papers
Simple synthesis method of biological orthogonal experiment E type olefin eight-membered ring marker
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Paragraph 0016; 0018; 0024, (2018/12/02)
The invention relates to a simple synthesis method of a biological orthogonal experiment E type olefin eight-membered ring marker. The simple synthesis method comprises the following steps: (a) dissolving a compound A in tetrahydrofuran and cooling until
Low catalyst loading in ring-closing metathesis reactions
Kadyrov, Renat
supporting information, p. 1002 - 1012 (2013/02/23)
An efficient procedure is described for ring-closing metathesis reactions. A conversion of 95 % for diethyl diallylmalonate in dilute solution could be achieved within a few minutes, reaching TOF=4173min-1, with very low loading of commercially available Ru catalysts that contained unsaturated NHC ligands. In general, only 50 to 250ppm of the catalyst is required to achieve near-quantitative conversion into a broad variety of 5-16-membered heterocyclic compounds. The practicality of this procedure was illustrated in the synthesis of 5-8-membered N-tert-butoxycarbonyl (N-Boc)- and N-para-toluenesulfonyl (N-Ts)-protected cyclic amines and 9-16-membered lactones. The synthesis of macrocyclic proline-based lactams required slightly higher catalyst loadings. Along with monocyclic products, oligomeric byproducts, mostly cyclodimers, were isolated and characterized. Getting some closure: An efficient procedure is described for ring-closing metathesis reactions in which only 50 to 250ppm of catalyst is required to effect almost-quantitative conversion into a broad range of 5-16-membered heterocyclic compounds. The practicality of this procedure was illustrated in the synthesis of 5-8-membered N-protected cyclic amines, 9-16-membered lactones, and 11-16-membered proline-based lactams. Copyright
Synthesis of N-heterocyclic diols by diastereoselective pinacol coupling reactions
Handa, Sandeep,Kachala, Manpreet S.,Lowe, Sarah R.
, p. 253 - 256 (2007/10/03)
A series of 5-8 membered N-heterocyclic diols have been prepared from acyclic dicarbonyls via diastereoselective pinacol reactions whereby cis- or trans-diol stereoselectivity is controlled by the choice of low-valent metal reagent used.
