4370-62-1 Usage
Uses
Used in Pharmaceutical Industry:
Coenzyme Q4 is used as a research compound for studying the effect of isoprenyl chain length on CoQ functions or distribution. It helps in understanding the role of CoQ compounds in various biological processes and their potential applications in drug development.
Used in Scientific Research:
Coenzyme Q4 is used as a comparative tool in research studies to investigate the impact of isoprenyl chain length on the functions and distribution of CoQ compounds. This aids in advancing the understanding of the role of CoQ in cellular processes and its potential therapeutic applications.
Biochem/physiol Actions
Increases the fluorescence polarization of perylene incorporated into ubiquinone-depleted mitochondrial and bilayer vesicles prepared from mitochondrial phospholipids
Purification Methods
It is a redoil which can be purified by chromatography on SiO2 plates and eluted with Et2O/hexane. The purity is checked by HPLC (silica column using 7% Et2O/hexane). It has max 270 nm ( 14,800) in pet ether. [NMR and MS: Naruta J Org Chem 45 4097 1980, cf Morton Biochemical Spectroscopy (Adam Hilger, London, 1975) p 491]. It has also been dissolved in MeOH/EtOH (1:1 v/v) and kept at 5o until crystals appear [Lester & Crane Biochim Biophys Acta 32 497 1958].
Check Digit Verification of cas no
The CAS Registry Mumber 4370-62-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,3,7 and 0 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 4370-62:
(6*4)+(5*3)+(4*7)+(3*0)+(2*6)+(1*2)=81
81 % 10 = 1
So 4370-62-1 is a valid CAS Registry Number.
InChI:InChI=1/C29H44O4/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-17-23(5)18-19-25-24(6)26(30)28(32-7)29(33-8)27(25)31/h12,14,16,18,28-29H,9-11,13,15,17,19H2,1-8H3/b21-14+,22-16+,23-18+
4370-62-1Relevant academic research and scientific papers
Controlling regiochemistry in negishi carboaluminations. Fine tuning the ligand on zirconium
Lipshutz, Bruce H.,Butler, Tom,Lower, Asher
, p. 15396 - 15398 (2007/10/03)
The species on the zirconocene catalyst is changed from two Cp's to the Brintzinger ligand and catalytic amounts of MAO are used to usually effect a >99% regiocontrol of Negishi carboaluminations of 1-alkynes in toluene. Copyright
Total Synthesis of Linear Polyprenoids. 3. Syntheses of Ubiquinones via Palladium-Catalyzed Oligomerization of Monoterpene Monomers
Eren, Doron,Keinan, Ehud
, p. 4356 - 4362 (2007/10/02)
A general methodology for highly regio- and stereoselective Pd(0)-catalyzed, stepwise allylic coupling of bifunctional monomers was developed, representing a practical approach for total synthesis of naturally occuring polyprenoids.As an example, the total synthesis of the cardiovascular agent ubiquinone 10 (coenzyme Q10), as well as shorter ubiquinones, was carried out via selective coupling of monomers easily derived from geraniol that contain either one or two reacting functional end groups.One of these funcionalities is a latent allylic electrophyle activated by the Pd(0) catalyst and the other is a latent nucleophile activated by an appropriate base.After the desired decaprenyl carbon skeleton of Q10 was achieved, the synthesis was completed by removal of the activating groups: Methyl ester was deleted via a highly efficient demethoxycarbonylation procedure involving 4-aminothiophenol and catalytic amounts of cesium carbonate, and the allylic sulfones were deleted by Pd(0)-catalyzed allylic reduction.Finally, oxidation of the aromatic ring to quinone affords ubiquinone 10.
