4373-67-5

Basic information

• Product Name: 3-(3-METHOXY-PHENYL)-PYRIDINE
• Synonyms: 3-(3-Methoxyphenyl)pyridine
• CAS NO: 4373-67-5
• Molecular Formula: C₁₂H₁₁NO
• Molecular Weight: 185.22
• Product Categories: Heterocycle-Pyridine series
• Mol File: 4373-67-5.mol
• Article Data: 33

Chemical Properties

• Boiling Point: 313.6 °C at 760 mmHg
• Flash Point: 115 °C
• Appearance: /
• Density: 1.077 g/cm³
• Vapor Pressure: 0.000906mmHg at 25°C
• Refractive Index: 1.56
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-(3-METHOXY-PHENYL)-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-METHOXY-PHENYL)-PYRIDINE(4373-67-5)
• EPA Substance Registry System: 3-(3-METHOXY-PHENYL)-PYRIDINE(4373-67-5)

Safety Data

• Hazardous Substances Data: 4373-67-5(Hazardous Substances Data)

Usage

General Description

3-(3-Methoxy-phenyl)-pyridine is a chemical compound with the molecular formula C12H11NO. It is a substituted pyridine derivative with a methoxyphenyl group attached to the third position of the pyridine ring. 3-(3-METHOXY-PHENYL)-PYRIDINE is commonly used in organic synthesis and pharmaceutical research. It has been studied for its potential pharmacological properties, including its role as a potential antifungal agent. Additionally, 3-(3-Methoxy-phenyl)-pyridine may have applications in materials science and the development of new chemicals for various industrial purposes. Overall, this compound has promising potential in several fields and is the subject of ongoing scientific investigation.

InChI:InChI=1/C12H11NO/c1-14-12-6-2-4-10(8-12)11-5-3-7-13-9-11/h2-9H,1H3

Upstream product

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• 89878-14-8 3-Diethylboranylpyridine 
• 858364-75-7 N,N-diethyl pyridin-3-yl O-sulfamate 
• 36282-40-3 (3-methoxyphenyl)magnesium bromide 
• 2398-37-0 3-methoxyphenyl bromide 
• 626-55-1 3-Bromopyridine 
• 10365-98-7 3-methoxyphenylboronic acid 
• 1692-25-7 3-pyridylboronic acid 
• 59-67-6 nicotinic acid 
• 109-97-7 pyrrole 
• 26113-44-0 3-methoxybenzene-1-carboximidamide hydrogenchloride 
• 591-31-1 3-methoxy-benzaldehyde 
• 99334-22-2 methyl 3-(3-methoxyphenyl)glycidate 
• 65292-99-1 2-(3-methoxyphenyl)acetaldehyde 

Downstream Products

• 93851-31-1 3-(pyridin-3-yl)phenol 
• 75240-91-4 1-propyl-3-(3-hydroxyphenyl)piperidine 
• 86562-23-4 (+/-)-3-(3-methoxyphenyl)-N-n-propylpiperidine 
• 89874-80-6 (+)-3-PPP hydrochloride 
• 79412-80-9 N-cyclohexyl-3-(3-methoxyphenyl)piperidine 
• 345620-22-6 N-n-butyl-3-(3-methoxyphenyl)piperidine 
• 79601-37-9 N-isopropyl-3-(3-methoxyphenyl)piperidine 
• 79412-47-8 3-(1-Benzyl-piperidin-3-yl)-phenol; hydrobromide 
• 79412-46-7 3-(1-Cyclohexyl-piperidin-3-yl)-phenol; hydrobromide 
• 79412-78-5 3-(1-Butyl-piperidin-3-yl)-phenol; hydrobromide 
• 79412-27-4 (+/-)-3-PPP hydrobromide 
• 79412-77-4 3-(1-Isopropyl-piperidin-3-yl)-phenol; hydrobromide 
• 79412-40-1 3-(1-Ethyl-piperidin-3-yl)-phenol; hydrobromide 
• 79412-38-7 3-(piperidin-3-yl)phenol hydrobromide 

Relevant articles and documents

Decarbonylative Pd-Catalyzed Suzuki Cross-Coupling for the Synthesis of Structurally Diverse Heterobiaryls

Heteroaromatic biaryls are core scaffolds found in a plethora of pharmaceuticals; however, their direct synthesis by the Suzuki cross-coupling is limited to heteroaromatic halide starting materials. Here, we report a direct synthesis of diverse nitrogen-containing heteroaromatic biaryls by Pd-catalyzed decarbonylative Suzuki cross-coupling of widely available heterocyclic carboxylic acids with arylboronic acids. The practical and modular nature of this cross-coupling enabled the straightforward preparation of >45 heterobiaryl products using pyridines, pyrimidines, pyrazines, and quinolines in excellent yields. We anticipate that the modular nature of this protocol will find broad application in medicinal chemistry and drug discovery research.

N-heterocyclic carbene coordinated heterogeneous Pd nanoparticles as catalysts for suzuki-miyaura coupling

Palladium nanoparticle (Pd NP) catalysts immobilized in a polymer with an N-heterocyclic carbene (NHC) moiety (PICBNHC-Pd) have been developed, wherein the NHC moiety plays dual roles as a crosslinker and a ligand to activate the Pd NPs. The presence of both Pd NPs and NHC was confirmed by STEM/EDS and SR-MAS NMR analyses, respectively. This PICB-NHC-Pd catalyst showed excellent activity in the Suzuki-Miyaura coupling reaction without leaching of Pd. Excellent results were obtained in gram-scale synthesis, and catalyst recovery/reuse experiments were completed without loss of catalyst activity.

Synthesis of 3-Arylpyridines via Palladium/Copper-Catalyzed Annulation of Allylamine/1,3-Propanediamine and Aldehydes

A novel and efficient method for the synthesis of 3-arylpyridines from allylamine/propanediamine and aldehydes by palladium/copper-catalyzed oxidative tandem cyclization has been developed. With this reaction, a series of desired 3-arylpyridines was synthesized in moderate yields via C-C/C-N bond formation and 6-endo/exo-trig cyclization.