4373-69-7Relevant academic research and scientific papers
COMPOUNDS USEFUL FOR INHIBITING CHK1
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Page/Page column 44, (2008/06/13)
Substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as ther-apeutic agents, for example, in treating cancer and oth
Synthesis and antiarrhythmic activity of disubstituted phenylpyridine derivative
Shigyo,Sato,Shibuya,Takahashi,Yamaguchi,Sonoki,Ohta
, p. 1573 - 1582 (2007/10/02)
A series of disubstituted phenylpyridine derivatives was synthesized and their antiarrhythmic effects against chloroform-induced ventricular arrhythmias in mice were examined. Among them, 2- and 3-[2-(3- aminobutyramido)-4-(2,2,2-trifluoroethoxy)phenyl]pyridines (23h, 24h) and 3- [2-(3-aminobutyramido)-4-ethoxyphenyl]pyridine (24i) showed potent antiarrhythmic activity. They had approximately twice the potency of mexiletine (III). Compound 24i was selected from this series as a candidate for further development; it was found to have a class I B electrophysiological character and to show a slow kinetic rate-dependent block (RDB) of the sodium channel in cardiac muscle.
