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2-(2,4-dichloro-benzyl)-2-aza-spiro[4.4]nonane-1,3-dione is a complex organic compound with the molecular formula C16H18Cl2N2O2. It features a spiro[4.4]nonane-1,3-dione core, which is a cyclic structure with a nine-membered ring containing two carbonyl groups (C=O). The compound is further characterized by a 2-aza group, indicating the presence of a nitrogen atom in the ring, and a 2,4-dichlorobenzyl substituent, which is a benzyl group (a phenylmethyl group) with two chlorine atoms attached at the 2nd and 4th positions on the benzene ring. This chemical structure is significant in the field of organic chemistry, potentially for its unique properties or reactivity, and may be of interest in the development of pharmaceuticals, agrochemicals, or other applications where complex organic molecules are utilized.

4375-56-8

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4375-56-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4375-56-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,3,7 and 5 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 4375-56:
(6*4)+(5*3)+(4*7)+(3*5)+(2*5)+(1*6)=98
98 % 10 = 8
So 4375-56-8 is a valid CAS Registry Number.

4375-56-8Downstream Products

4375-56-8Relevant academic research and scientific papers

Synthesis, physicochemical and anticonvulsant properties of N-benzyl and N-aminophenyl derivatives of 2-azaspiro[4.4]nonane and [4.5]decane-1,3-dione. Part I

Obniska, Jolanta,Dzierzawska-Majewska, Agnieszka,Zagorska, Agnieszka,Zajdel, Pawel,Karolak-Wojciechowska, Janina

, p. 529 - 539 (2005)

To continue our systematic SAR studies, two series of N-benzyl- (X = CH2) and N-aminophenyl- (X = NH) derivatives of 2-azaspiro[4.4]nonane (1a-1j) and 2-azaspiro[4.5]decane-1,3-dione (2a-2j) were synthesized, and evaluated in maximum electroshock seizure (MES), subcutaneous pentylenetetrazole (sc.MET) and rotorod (TOX) tests for their anticonvulsant activity. Among those derivatives, the most potent N-aminophenyl-2-azaspiro[4.4]nonane-1,3-dione 1j had ED50 = 76.27 mg kg-1. X-ray structures for two pairs of derivatives with a different linker were solved. Then 3-D data for the active 1j versus less active 2j, both having an imine linker (X = NH), and the respective parent of compounds with a methylene linker (X = CH2) (1a and 2a) were discussed.

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