437606-60-5

Upstream product

• 5518-62-7 1,2-diphosphinoethane 
• 757954-43-1 (4S)-4-benzyl-1,3,2-dioxathiepane-2,2-dioxide 
• 437606-60-5 1,2-bis((1S,2R)-2-benzylphospholano)ethane 
• 757954-64-6 (S)-5-phenyl-pentane-1,4-diol 

Downstream Products

• 437606-60-5 1-((1R,2R)-2-benzylphospholan-1-yl)-2-((1S,2R)-2-benzylphospholan-1-yl)-ethane 

Relevant academic research and scientific papers

Preparation of P-chirogenic phospholanes and their use in asymmetric synthesis

Materials and methods for preparing P-chirogenic monophospholanes and bisphospholanes are disclosed. The methods employ stereoselective cyclization to generate the phospholane rings followed by pyramidal inversion to access a variety of P-chirogenic phosp

Stereoselective cyclization and pyramidal inversion strategies for P-chirogenic phospholane synthesis

Preparation of P-chirogenic mono- and bisphospholanes is reported. The demonstrated method employs a stereoselective cyclization of cyclic sulfates with primary phosphines in the presence of base to generate "cis" or "cis/cis" P-chirogenic phospholanes followed by heat-induced pyramidal inversion to provide "trans" or "trans/trans" P-chirogenic phospholanes. A rhodium complex of one "trans/trans" phospholane is applied to the highly enantioselective asymmetric hydrogenation of a substrate precursor to the pharmaceutical candidate pregabalin. Copyright