437608-53-2Relevant academic research and scientific papers
A convenient one-pot synthesis of phosphino-dipeptide analogs
Pirat, Jean-Luc,Coulombeau, Agnes,Genevois-Borella, Arielle,Cristau, Henri-Jean
, p. 1793 - 1796 (2007/10/03)
A general "one-pot" synthetic method is described for the preparation of phosphinodipeptides of type 1, in 60-80% overall yield, allowing the variation of the substituents in α and/or β position to the phosphorus atom and also in α position to the nitrogen atom.
Preparation of phosphinodipeptide analogs as building blocks for pseudopeptides synthesis
Cristau, Henri-Jean,Coulombeau, Agnès,Genevois-Borella, Arielle,Sanchez, Frédéric,Pirat, Jean-Luc
, p. 381 - 391 (2007/10/03)
A simple and effective preparation of phosphinodipeptides, in good overall yields, has been developed. This one pot procedure, allowing the variation of the substituents in α and/or β position to the phosphorus atom and also in α position to the nitrogen atom, consists in the addition of alkyl hypophosphites to imines, followed by Michael-addition on acrylates. To show the value of phosphinodipeptides analogs 1 as synthetic intermediates, selective deprotections of the three functional groups are described.
