80993-23-3Relevant academic research and scientific papers
Method of synthesis of phosphinic acids based on hypophosphites: VIII.1 synthesis of α-aminoalkylphenethylphosphinic acids
Dmitriev,Ragulin
, p. 1786 - 1791 (2011)
Development of methodology of double Arbuzov rearrangement based on hypophosphites allows a one-pot formation of two unsymmetrical phosphorus-carbon bonds by the Michael-Pudovik type reaction of stepwise addition of the intermediately forming silyl esters of trivalent phosphorus to different unsaturated compounds. A procedure was developed of the synthesis of α-aminoalkylphenethylphosphinic acids. Bis-(trimethylsilyl) phenethylphosphonite formed as a result of the addition of bis(trimethylsilyl) hypophosphite to styrene in situ was added without isolation from the reaction mixture to Schiff bases obtained preliminary from benzylamine or diphenylmethylamine and various aldehydes. The subsequent removal of N-protecting groups by hydrogenation or acidic hydrolysis gave a number of new α-aminoalkylphenethylphosphinic acids.
Synthesis of 1-Aminoalkane Phosphonic Acids via Benzhydrylic Schiff Bases
Issleib, Kurt,Doepfer, Klaus-Peter,Balszuweit, Arno
, p. 1392 - 1394 (2007/10/02)
A simple synthesis of 1-aminoalkanephosphonic acids is described.The addition of diethylphosphite to alkylidene- and arylidenebenzhydrylamines yields the N-benzhydryl-1-aminoalkanephosphonic acid esters.The title compounds are formed by treatment of the N-blocked esters with hydrobromic acid.The starting amine can be recycled from the hydrylbromide. - Key words: 1-Aminoalkane Phosphonic Acids, Benzhydrylic, Schiff Bases
