437707-51-2

Usage

Uses

Used in Pharmaceutical Research and Development:
4-AMINO-3-BROMO-5-IODO-BENZOIC ACID ETHYL ESTER is used as a key intermediate in the synthesis of pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 4-AMINO-3-BROMO-5-IODO-BENZOIC ACID ETHYL ESTER is used as a versatile building block for the creation of a wide range of organic compounds. Its presence of both bromine and iodine atoms, along with an amino group, makes it a valuable component in the synthesis of complex organic molecules.
Used in Chemical Production:
4-AMINO-3-BROMO-5-IODO-BENZOIC ACID ETHYL ESTER is utilized in the production of various organic compounds, contributing to the development of new materials and chemical entities with diverse applications.
Safety Precautions:
It is crucial to handle and store 4-AMINO-3-BROMO-5-IODO-BENZOIC ACID ETHYL ESTER with appropriate safety measures, as it may pose health risks if ingested or inhaled and can cause skin and eye irritation. Proper handling and storage protocols should be followed to minimize potential hazards.

Upstream product

• 7149-03-3 ethyl 3-bromo-4-aminobenzoate 
• 94-09-7 p-aminoethylbenzoate 

Downstream Products

• 186772-44-1 ethyl 3-bromo-5-iodobenzoate 
• 437707-17-0 C₆₃H₉₃BrO₄Si 
• 437707-01-2 C₆₃H₉₄O₄Si 
• 437706-90-6 C₅₆H₈₂O₄Si₂ 
• 437707-15-8 C₄₇H₆₁BrO₄Si 
• 437706-98-4 C₄₇H₆₂O₄Si 
• 437707-03-4 C₃₆H₃₈O₁₀ 
• 437706-96-2 C₃₈H₄₂O₄ 
• 437706-83-7 octyl 3-ethynyl-5-[(triisopropylsilyl)ethynyl]benzoate 
• 437706-92-8 C₇₂H₁₁₄O₄Si₂ 
• 186772-50-9 C₅₄H₇₄O₄ 
• 437706-86-0 hexadecyl 3-ethynyl-5-[(triisopropylsilyl)ethynyl]benzoate 
• 186772-46-3 ethyl 3-[(trimethylsilyl)ethynyl]-5-[(triisopropylsilyl)ethynyl]benzoate 
• 437707-54-5 ethyl 3-bromo-5-[(triisopropylsilyl)ethynyl]benzoate 

Relevant academic research and scientific papers

m-Diethynylbenzene macrocycles: Syntheses and self-association behavior in solution

m-Diethynylbenzene macrocycles (DBMs), buta-1,3-diyne-bridged [4n]metacyclophanes, have been synthesized and their self-association behaviors in solution were investigated, Cyclic tetramers, hexamers, and octamers of DBMs having exo-annular octyl, hexadecyl, and 3,6,9-trioxadecyl ester groups were prepared by intermolecular oxidative coupling of dimer units or intramolecular cyclization of the corresponding open-chain oligomers. The aggregation properties were investigated by two methods, the 1H NMR spectra and the vapor pressure osmometry (VPO). Although some discrepancies were observed between the association constants obtained from the two methods, the qualitative view was consistent with each other. The analysis of self-aggregation by VPO revealed unique aggregation behavior of DBMs in acetone and toluene, which was not elucidated by the NMR method. Namely, the association constants for infinite association are several times larger than the dimerization constant, suggesting that the aggregation is enhanced by the formation of dimers (a nucleation mechanism). In polar solvents, DBMs aggregate more strongly than in chloroform due to the solvophobic interactions between the macrocyclic framework and the solvents. Moreover, DBMs self-associate in aromatic solvents such as toluene and o-xylene more readily than in chloroform. In particular, the hexameric DBM having a large macrocyclic cavity exhibits extremely large association constants in aromatic solvents. By comparing the aggregation properties of DBMs with the corresponding acyclic oligomers, the effect of the macrocyclic structure on the aggregation propensity was clarified. Finally, it turned out that DBMs tend to aggregate more readily than the corresponding phenylacetylene macrocycles, acetylene-bridged [2n]metacyclophanes, owing to the withdrawal of the electron density from the aromatic rings by the butadiyne linkages which facilitates π-π stacking interactions.

Synthesis and self-association properties of diethynylbenzene macrocycles

We synthesized diethynylbenzene macrocycles (DBMs), cyclic oligomers of diethynylbenzene, having functional groups in the periphery of the macrocyclic framework and investigated their self-association properties in solution resulting from π-π stacking interaction. The tetrakis-DBM having hexadecyl ester groups showed dimerization behavior not only in chloroform-d, but also in o-dichlorobenzene-4.