10449-07-7

Basic information

• Product Name: (2-CHLOROPHENYL)HYDRAZINE HYDROCHLORIDE
• Synonyms: Hydrazine,(2-chlorophenyl)-;1-Chloro-2-hydrazinobenzene
• CAS NO: 10449-07-7
• Molecular Formula: C₆H₇ClN₂
• Molecular Weight: 142.5862
• EINECS: 255-194-1
• Mol File: 10449-07-7.mol
• Article Data: 14

Chemical Properties

• Melting Point: 47 °C
• Boiling Point: 252.1 °C at 760 mmHg
• Flash Point: 106.2 °C
• Appearance: /
• Density: 1.32 g/cm³
• Vapor Pressure: 0.0197mmHg at 25°C
• Refractive Index: 1.655
• PKA: 4.60±0.10(Predicted)
• CAS DataBase Reference: (2-CHLOROPHENYL)HYDRAZINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (2-CHLOROPHENYL)HYDRAZINE HYDROCHLORIDE(10449-07-7)
• EPA Substance Registry System: (2-CHLOROPHENYL)HYDRAZINE HYDROCHLORIDE(10449-07-7)

Safety Data

• Hazardous Substances Data: 10449-07-7(Hazardous Substances Data)

Usage

Uses

1-(2-chlorophenyl)hydrazine is a useful research reagent used in the preparation of halogen-substituted phenylhydrazine derivatives with antifungal properties.

InChI:InChI=1/C6H7ClN2/c7-5-3-1-2-4-6(5)9-8/h1-4,9H,8H2

Upstream product

• 857595-49-4 o-chloronitroaniline 
• 95-51-2 o-chloroaniline 
• 50-81-7 ascorbic acid 
• 7647-01-0 hydrogenchloride 
• 89-90-7 2-chlorobenzenediazonium chloride 
• 79984-70-6 N’-(2-chlorophenyl)benzohydrazide 
• 1956-97-4 2-chlorobenzenediazonium tetrafluoroborate 
• 952-53-4 1,3-diphenyl-2,3-diazaprop-2-en-1-one 
• 17333-83-4 2-chlorobenzenediazonium 

Downstream Products

• 133690-83-2 5-n-Butyl-2-(2-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 928053-21-8 (4S,7R)-2-(2-chloro-phenyl)-7,8,8-trimethyl-1,2,4,5,6,7-hexahydro-4,7-methano-indazol-3-one 
• 220000-29-3 ethyl 2-benzoylamino-3-[(2-chlorophenyl)hydrazono]propanoate 
• 3296-07-9 1-azido-2-chlorobenzene 
• 108-90-7 chlorobenzene 
• 14723-82-1 N-Benzyloxycarbonyl-L-phenylalanin-o-chlor-phenylhydrazid 
• 14723-81-0 N-Benzyloxycarbonyl-L-alanin-o-chlor-phenylhydrazid 
• 14746-08-8 N-Benzyloxycarbonyl-L-leucin-o-chlor-phenylhydrazid 
• 14746-07-7 N-Benzyloxycarbonyl-glycin-o-chlor-phenylhydrazid 
• 111205-85-7 L-threo-2,3-Hexodiulosono-1,4-lacton-2-(o-chlor-phenylhydrazon) 
• 145159-69-9 adipaldehyde-3,4-dicarboximide bis(2-chlorophenylhydrazone) 
• 79005-97-3 1-(2-Chloro-phenylamino)-3-phenyl-1,3-dihydro-indol-2-one 
• 79326-49-1 2-(2-Chloro-phenyl)-4-(2-chloro-phenylazo)-5-methyl-2,4-dihydro-pyrazol-3-one 
• 81761-76-4 1-(2-Chloro-phenyl)-4-methyl-5,5-dioxo-4,5-dihydro-1H-5λ⁶-thia-1,2,4-triaza-cyclopenta[a]naphthalene-3-carboxylic acid methyl ester 

Relevant articles and documents

Discovery of novel inhibitors of human phosphoglycerate dehydrogenase by activity-directed combinatorial chemical synthesis strategy

Serine, the source of the one-carbon units essential for de novo purine and deoxythymidine synthesis plays a crucial role in the growth of cancer cells. Phosphoglycerate dehydrogenase (PHGDH) which catalyzes the first, rate-limiting step in de novo serine biosynthesis has become a promising target for the cancer treatment. Here we identified H-G6 as a potential PHGDH inhibitor from the screening of an in-house small molecule library based on the enzymatic assay. We adopted activity-directed combinatorial chemical synthesis strategy to optimize this hit compound. Compound b36 was found to be the noncompetitive and the most promising one with IC50 values of 5.96 ± 0.61 μM against PHGDH. Compound b36 inhibited the proliferation of human breast cancer and ovarian cancer cells, reduced intracellular serine synthesis, damaged DNA synthesis, and induced cell cycle arrest. Collectively, our results suggest that b36 is a novel PHGDH inhibitor, which could be a promising modulator to reprogram the serine synthesis pathway and might be a potential anticancer lead worth further exploration.

Method for synthesizing 1-(2,4-dichlorophenyl)-3-methyl-4-difluoromethyl-1,2,4-triazole-5-ketone

The invention discloses a method for synthesizing 1-(2,4-dichlorophenyl)-3-methyl-4-difluoromethyl-1,2,4-triazole-5-ketone. The method comprises the following steps: with o-chloroaniline as a raw material, carrying out diazotization, reduction and salific

Regioselective radical arylation of anilines with arylhydrazines

Substituted 2-aminobiphenyls have been prepared from arylhydrazines and anilines via radical arylation reactions under simple oxidative conditions. The strong directing effect of the free and unprotonated amino functionality leads to high regioselectivities, and anilines have been shown to be significantly better aryl radical acceptors than nitrobenzenes or phenyl ethers. The methodology is also applicable to phenols, which react best as phenolates under strongly basic conditions. Finally, radical arylation reactions of anilines and anilinium salts under various conditions have for the first time demonstrated that regioselectivity can also be controlled through the rearomatization step and that the addition of an aryl radical to a substituted benzene might even be reversible.