437761-36-9

Upstream product

• 437761-34-7 [3-[benzyloxycarbonyl-(3-trifluoromethyl-benzyl)-amino]-6-(tert-butoxycarbonyl-phenyl-aminocarbonyl)-8-methyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidin-8-yl]-acetic acid benzyl ester 
• 437761-33-6 benzyl ((6S,8S)-6-(anilinocarbonyl)-3-{[(benzyloxy)carbonyl][3-(trifluoromethyl)benzyl]amino}-8-methyl-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidin-8-yl)acetate 
• 437761-32-5 ((6S,8S)-6-(Anilinocarbonyl)-3-{[(benzyloxy)carbonyl][3-(trifluoromethyl)benzyl]amino}-8-methyl-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidin-8-yl)acetic acid 
• 100-39-0 benzyl bromide 
• 208521-42-0 (1R)-1-aminopropyl boronic acid pinanediol ester 
• 437761-35-8 (6S,8S)-3-{[(Benzyloxy)carbonyl][3-(trifluoromethyl)benzyl]amino}-8-[2-(benzyloxy)-2-oxoethyl]-8-methyl-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxylic acid 

Downstream Products

• 437761-37-0 ((6S,8S)-6-[({(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]propyl}amino)carbonyl]-8-methyl-4-oxo-3-{[3-(trifluoromethyl)benzyl]amino}-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidin-8-yl)acetic acid 

Relevant academic research and scientific papers

Design and synthesis of bicyclic pyrimidinone-based HCV NS3 protease inhibitors

A series of bicyclic pyrimidinone-based HCV NS3 protease inhibitors was synthesized via selective C8 position functionalization. Substituted phenylamides and phenylureas were preferred in the S2 binding pocket.

Inhibitors of hepatitis C virus NS3 protease

The present invention relates generally to a novel class of pyrimidinones of Formula (I): that are useful as serine protease inhibitors, and more particularly as Hepatitis C virus NS3 protease inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.