437768-39-3Relevant academic research and scientific papers
Novel thiazolones as HCV NS5B polymerase allosteric inhibitors: Further designs, SAR, and X-ray complex structure
Yan, Shunqi,Larson, Gary,Wu, Jim Z.,Appleby, Todd,Ding, Yili,Hamatake, Robert,Hong, Zhi,Yao, Nanhua
, p. 63 - 67 (2007/10/03)
Structure-activity relationships (SAR) of 1 against HCV NS5B polymerase were described. SAR explorations and further structure-based design led to the identifications of 2 and 3 as novel HCV NS5B inhibitors. X-ray structure of 3 in complex with NS5B polymerase was obtained at a resolution of 2.2 A, and confirmed the design.
An expedient route to the tetrazole analogues of α-amino acids
Demko, Zachary P.,Sharpless, K. Barry
, p. 2525 - 2527 (2007/10/03)
(Matrix presented) Convenient conditions are described for the transformation of α-aminonitriles to the tetrazole analogues of α-amino acids. Refluxing the starting material in water/2-propanol at 80 °C with sodium azide and catalytic zinc bromide affords
