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Usage

Uses

Used in Pharmaceutical Industry:
[1,1'-Biphenyl]-2-amine, 2'-(trifluoromethyl)is used as a building block for the development of new pharmaceuticals. Its incorporation into drug molecules can improve their bioactivity and metabolic stability, making it a crucial component in the creation of effective medications.
Used in Agrochemical Industry:
In the agrochemical sector, [1,1'-Biphenyl]-2-amine, 2'-(trifluoromethyl)is utilized as a key intermediate in the synthesis of various agrochemicals. Its unique properties can lead to the development of more effective and stable products for agricultural applications.
Used in Organic Synthesis:
[1,1'-Biphenyl]-2-amine, 2'-(trifluoromethyl)is also used as an intermediate in organic synthesis, allowing for the preparation of a wide range of organic compounds. Its versatility and the unique properties conferred by the trifluoromethyl group make it a valuable asset in the synthesis of diverse chemical products.

Upstream product

• 577-19-5 2-nitrophenyl bromide 
• 615-43-0 2-iodophenylamine 
• 1423-27-4 2-(trifluoromethyl)phenylboronic acid 
• 444-29-1 2-iodo(trifluoromethyl)benzene 
• 2613-39-0 2-nitro-2'-(trifluoromethyl)-1,1'-biphenyl 

Downstream Products

• 76838-68-1 1-Benzoyl-3-(2'-trifluoromethyl-biphenyl-2-yl)-thiourea 

Relevant academic research and scientific papers

Broad activity of diphenyleneiodonium analogues against Mycobacterium tuberculosis, malaria parasites and bacterial pathogens

In this study, a structure-activity relationship (SAR) compound series based on the NDH-2 inhibitor diphenyleneiodonium (DPI) was synthesised. Compounds were evaluated primarily for in vitro efficacy against Gram-positive and Gram-negative bacteria, commonly responsible for nosocomial and community acquired infections. In addition, we also assessed the activity of these compounds against Mycobacterium tuberculosis (Tuberculosis) and Plasmodium spp. (Malaria). This led to the discovery of highly potent compounds active against bacterial pathogens and malaria parasites in the low nanomolar range, several of which were significantly less toxic to mammalian cells.

Synthesis of the Carbazole Scaffold Directly from 2-Aminobiphenyl by Means of Tandem C–H Activation and C–N Bond Formation

An efficient method for the synthesis of the carbazole scaffold was designed and investigated. The method was developed to produce substituted carbazoles by an intramolecular combination of a free amine group and an arene. The steps of the method involved tandem Pd-catalyzed C–H activation and intramolecular C–N bond formation. The method showed good functional group tolerance, and substituent(s) could be on either of the two rings or on both of the two rings of the 2-aminobiphenyl substrate. After ring closure, the reduced Pd catalyst was oxidized to PdIIby hydrogen peroxide. The novel method was also demonstrated to operate excellently with the corresponding 2-N-acetylaminobiphenyls.

Imidazoline derivatives as alpha-1A adrenoceptor ligands

Compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof are disclosed. Such compounds are useful in the treatment of Alpha-1A mediated diseases or conditions such as urinary incontinence.