438019-72-8

Upstream product

• 314250-25-4 1-(2-nitro-4-(trifluoromethyl)phenyl)-1H-1,2,4-triazole 
• 121-17-5 2-chloro-3-nitro-5-trifluoromethylbenzene 
• 122-01-0 4-chloro-benzoyl chloride 
• 438019-67-1 [2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethyl)phenyl]amine 

Downstream Products

• 380196-56-5 4-chloro-N-[2-{5-[dimorpholinophosphothioyl]-1H-1,2,4-triazole-1-yl}-5-trifluoromethyl]benzamide 
• 441312-27-2 (4-bromo-7-trifluoromethyl-4H-1,3,5,9b-tetraaza-4-phospha-cyclopenta[a]naphthalen-5-yl)-(4-chloro-phenyl)-methanone 

Relevant academic research and scientific papers

C-phosphorylation of 1,2,4-triazoles with phosphorus(III) halides. Synthesis of 4,5-dihydrobenzo[e][1,2,4]triazolo[5,1-c] [1,4,2] diazaphosphinine derivatives

Phosphorylation of 4- and 1-substituted 1,2,4-triazoles with PCl3, PhPCl2, Ph2PCl, and (Et2N)2 PCl was carried out. A novel phosphorus-containing condensed heterocyclic system (18, 23) was constructed by the reactions of 2-(1H-1,2,4-triazol-1-yl)1-(4-chlorophenylcarboxamido)-5-trifluoromethylbenzene with PBr3 and PhPBr2. Treatment of the bromophosphonite 18 with an excess of morpholine in the presence of sulfur resulted in a diazaphosphinine ring opening and provided functionalized 1H-1,2,4-triazol-5-ylphosphonic acid derivatives 21 and 22.