438052-57-4Relevant academic research and scientific papers
N-substituted piperazines
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Page/Page column 13, (2010/11/25)
Novel N-alkyl substituted piperazines have been discovered, which are useful as insecticides or fungicides. Such compounds are of Formula (I) wherein X, Y, R1 and R2 are as defined herein.
Piperazinyl benzamidines: Synthesis and affinity for the delta opioid receptor
Nortey, Samuel O.,Baxter, Ellen W.,Codd, Ellen E.,Zhang, Sui-Po,Reitz, Allen B.
, p. 1741 - 1743 (2007/10/03)
Piperazinyl benzamidines were prepared and found to bind to the rat delta (δ) opioid receptor. The most active compounds had a N,N-diethylcarboxamido group and a N-benzyl piperazine. The most potent among these was N,N-diethyl-4-[4-(phenylmethyl)-1-piperazinyl][2- (trifluoromethyl)phenyl]iminomethyl]benzamide (27) with a 1.22 nM Ki for the rat δ opioid receptor and ca. 1000× selectivity relative to the μ opioid subtype.
