438216-17-2Relevant articles and documents
Synthesis of a potent antagonist of E-selectin.
Hanessian, Stephen,Mascitti, Vincent,Rogel, Olivier
, p. 3346 - 3354 (2007/10/03)
A synthesis of an antagonist of E-selectin previously reported by a group at Novartis Pharma in Basel is described. An important feature involves the formation of an ether linkage based on a Rh(II)-catalyzed reaction. Stereocontrolled glycosylations rely on the anomeric activation of 2-pyridylthio carbonate as leaving group for the attachment of beta-D-galactopyranosyl and alpha-L-fucopyranosyl units on a common 1,5-anhydro D-glucitol scaffold.