438216-18-3

Upstream product

• 135214-83-4 1,5-Anhydro-2-deoxy-4,6-O-(phenylmethylene)-D-arabino-hexopyranoside 
• 438216-16-1 (2,3,4-tri-O-benzyl-α-L-fucopyranosyl)-O-(1->4)-3-O-benzoyl-6-O-benzyl-1,2,-dideoxy-D-glucopyranose 
• 438216-15-0 3-O-benzoyl-6-O-benzyl-1,2-dideoxy-D-glucopyranose 
• 438216-14-9 3-O-benzoyl-4,6-O-benzylidene-1,2-dideoxy-D-glucopyranose 
• 160776-15-8 2,3,4-tri-O-benzyl-β-L-fucopyranosyl 2-thiopyridyl carbonate 
• 162118-38-9 (3S,4R,5R,6S)-3,4,5-tris(benzyloxy)-6-methyltetrahydro-2H-pyran-2-ol 
• 438216-17-2 (2,3,4-tri-O-benzyl-α-L-fucopyranosyl)-O-(1->4)-6-O-benzyl-1,2,-dideoxy-D-glucopyranose 
• 438216-13-8 2-O-benzoyl-4,6-O-benzylidene-3-O-[(S)-1-(methoxycarbonyl)-2-cyclohexylethyloxy]-β-D-galactopyranosyl 2-thiopyridyl carbonate 

Downstream Products

• 438216-19-4 (2-O-benzoyl-4,6-O-benzylidene-3-O-[(S)-1-(oxycarbonyl)-2-cyclohexylethyloxy]-β-D-galactopyranosyl-O-(1->3)-[(2,3,4-tri-O-benzyl-α-L-fucopyranosyl)-O-(1->4)]-6-O-benzyl-1,2-dideoxy-D-glucopyranose 
• 438216-20-7 (4,6-O-benzylidene-3-O-[(S)-1-(oxycarbonyl)-2-cyclohexylethyloxy]-β-D-galactopyranosyl-O-(1->3)-[(2,3,4-tri-O-benzyl-α-L-fucopyranosyl)-O-(1->4)]-6-O-benzyl-1,2-dideoxy-D-glucopyranose 

Relevant academic research and scientific papers

Synthesis of a potent antagonist of E-selectin.

A synthesis of an antagonist of E-selectin previously reported by a group at Novartis Pharma in Basel is described. An important feature involves the formation of an ether linkage based on a Rh(II)-catalyzed reaction. Stereocontrolled glycosylations rely on the anomeric activation of 2-pyridylthio carbonate as leaving group for the attachment of beta-D-galactopyranosyl and alpha-L-fucopyranosyl units on a common 1,5-anhydro D-glucitol scaffold.