438229-79-9

Usage

Uses

Used in Pharmaceutical Industry:
4-(2-Oxo-2-pyrrolidin-1-yl-ethoxy)-benzaldehyde is used as an intermediate in the synthesis of pharmaceutical compounds for its potential biological activity. Its unique structure allows for the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 4-(2-Oxo-2-pyrrolidin-1-yl-ethoxy)-benzaldehyde is used as a precursor in the production of various agrochemicals, potentially contributing to the development of new pesticides or other agricultural chemicals.
Used in Research and Development:
4-(2-Oxo-2-pyrrolidin-1-yl-ethoxy)-benzaldehyde serves as a key compound in research and development efforts, where its reactivity and structural features are explored for the creation of novel organic molecules with potential applications in various fields.
Given the compound's potential applications and the interest from researchers in medicinal chemistry, further investigation into its biological activity and synthesis capabilities is warranted to unlock its full potential across different industries.

InChI:InChI=1/C13H15NO3/c15-9-11-3-5-12(6-4-11)17-10-13(16)14-7-1-2-8-14/h3-6,9H,1-2,7-8,10H2

Upstream product

• 123-75-1 pyrrolidine 
• 22042-71-3 (4-formylphenoxy)acetic acid 
• 20266-00-6 chloroacetic acid pyrrolidide 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 663205-96-7 5-(4-(2-oxo-2-(pyrrolidin-1-yl)ethoxy)benzylidene)-2-thioxodihydro-pyrimidine-4,6(1H,5H)-dione 

Relevant academic research and scientific papers

Design and synthesis of some barbituric and 1,3-dimethylbarbituric acid derivatives: A non-classical scaffold for potential PARP1 inhibitors

Six series based on barbituric acid 5a-e, 10a-d; thiobarbituric acid 6a-e, 11a-d and 1,3-dimethylbarbituric acid 7a-e, 12a-d were prepared and screened for their in vitro PARP1 inhibition. They revealed promising inhibition at nanomolar level especially compounds 5c, 7b, 7d and 7e (IC50 = 30.51, 41.60, 41.53 and 36.33 nM) with higher potency than olaparib (IC50 = 43.59 nM). Moreover, compounds 5b, 5d, 7a, 12a and 12c exhibited good comparable activity (IC50 = 65.93, 58.90, 66.57, 45.40 and 50.62 nM, respectively). Furthermore, the most active compounds 5c, 7b, 7d, 7e, 12a and 12c against PARP1 in vitro were evaluated in the BRCA1 mutated triple negative breast cancer cell line MDA-MB-436 where 5c and 12c showed higher potency compared to olaparib and result in cell cycle arrest at G2/M phase. 5c and 12c showed apoptotic effects in MDA-MB-436 and potentiated the cytotoxicity of temozolomide in A549 human lung epithelial cancer cell line. Compounds 5c and 12c represent interesting starting points towards PARP1 inhibitors.

SUBSTITUTED 1-AMINOPHTHALAZINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF

The invention concerns 1-amino-phthalazine derivatives of general formula (I): Wherein A, B, L, R, R1, R2, R3, R4, R5 and R7 are as defined herein. The invention also concerns the preparation of said compounds and their therapeutic use.