438243-87-9

Usage

Uses

Used in Pharmaceutical Research:
5-AMINO-1-(4-BROMO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID is used as a building block or intermediate for the synthesis of various biologically active compounds, including pharmaceutical drugs. Its potential bioactivity makes it a promising candidate for the development of new therapeutic agents for the treatment of various diseases.
Used in Agrochemicals:
In the agrochemical industry, 5-AMINO-1-(4-BROMO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID is used as a key intermediate in the synthesis of agrochemicals, contributing to the development of effective and environmentally friendly solutions for pest control and crop protection.
Used in Organic Synthesis:
5-AMINO-1-(4-BROMO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID is utilized as a versatile building block in organic synthesis, enabling the creation of a wide range of chemical compounds with diverse applications in various industries.
Used in Drug Design and Discovery:
Due to its unique structure and properties, 5-AMINO-1-(4-BROMO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID is used as a valuable tool for studying structure-activity relationships in drug design and discovery, aiding researchers in understanding the molecular interactions and optimizing the therapeutic potential of new drug candidates.

InChI:InChI=1/C10H8BrN3O2/c11-6-1-3-7(4-2-6)14-9(12)8(5-13-14)10(15)16/h1-5H,12H2,(H,15,16)

Upstream product

• 138907-71-8 ethyl 5-amino-1-(4-bromophenyl)-1H-pyrazole-4-carboxylate 
• 622-88-8 4-bromophenylhydrazine hydrochloride 

Downstream Products

• 1235034-86-2 1-(4-bromophenyl)-1H-pyrazolo[3,4-d]pyrimidine 
• 1235034-87-3 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-pyrazolo[3,4-d]pyrimidine 
• 1235034-88-4 4-(1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenol 

Relevant academic research and scientific papers

Synthesis of pyrazole-carboxamides and pyrazole-carboxylic acids derivatives: Simple methods to access powerful building blocks

Hybrid systems containing pyrazole moiety show a wide spectrum of biological activities. To access novel hybrids with pyrazole ring, in this work we synthesized twenty pyrazole-carboxylic acids and twenty pyrazole-carboxamides, using simple synthetic methods, to be used as building blocks in the development of new structures.

Discovery of a potent and selective BCL-XLinhibitor with in vivo activity

A-1155463, a highly potent and selective BCL-XLinhibitor, was discovered through nuclear magnetic resonance (NMR) fragment screening and structure-based design. This compound is substantially more potent against BCL-XL-dependent cell lines relative to our recently reported inhibitor, WEHI-539, while possessing none of its inherent pharmaceutical liabilities. A-1155463 caused a mechanism-based and reversible thrombocytopenia in mice and inhibited H146 small cell lung cancer xenograft tumor growth in vivo following multiple doses. A-1155463 thus represents an excellent tool molecule for studying BCL-XLbiology as well as a productive lead structure for further optimization.

HETEROCYCLIC COMPOUNDS AND METHODS OF USE

In one aspect, the present invention provides for a compound of Formula I; in which the variable X1a, X1b, X1c, X1d, Q, A, R1, B, L, E, and the subscripts m and n have the meanings as described herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-xL proteins.

Antibacterial compounds

The present invention provides compounds having useful antibacterial activity and pharmaceutical compositions comprising one or more of these compounds. The invention further relates to a method of treating a bacterial infection in a patient, comprising a