438458-40-3Relevant academic research and scientific papers
Silica-supported ceric ammonium nitrate (CAN): a simple, mild and solid-supported reagent for quickest oxidative aromatization of Hantzsch 1,4-dihydropyridines
Kumar, Parvin,Kadyan, Kulbir,Duhan, Meenakshi,Sindhu, Jayant,Hussain, Khalid,Lal, Sohan
, p. 1153 - 1162 (2019/04/25)
An efficient and environmentally benign methodology for the oxidative aromatization of 1,4-dihydropyridines to their corresponding pyridine derivatives is developed. The oxidative aromatization of 1,4-dihydropyridines was explored using silica-supported ceric ammonium nitrate as catalyst in CH3CN with or without sonication at room temperature. This supported catalyst acts as a more efficient oxidising reagent and offers several advantages over other reported reagents in terms of reaction time and yields. The supported reagent is found to be more efficient and selective when compared with its unsupported form. The Belousov–Zhabotinskii reaction was not observed in present reaction. The dealkylation observed in case of 4-n-alkyl/n-alkenyl with other oxidising agents is also not observed in the present case.
CAN mediated mechanochemical synthesis of substituted pyridine derivatives
Khanna, Radhika,Dalal, Aarti,Kadyan, Kulbir,Kumar, Ramesh,Kumar, Parvin,Kamboj, Ramesh C.
, p. 673 - 677 (2018/07/14)
A simple, green and cost-effective protocol has been devised for the synthesis of 4-substituted-2,6-dimethyl-3,5-pyridinecarboxylates from Hantzsch-type 1,4-dihydropyridines via rapid oxidation in excellent yields using 1.5 equivalent of ceric ammonium nitrate within 15 minutes in solvent-free conditions. The method was able to furnish the products in excellent yields. The products obtained were characterized by their NMR and melting points data.
An efficient, three-component one-pot preparation of 1,4-dihydropyridines containing novel substituted pyrazole under sulfamic acid catalysis
Li, Jianping,Qiu, Jikuan,Li, Huijuan,Zhang, Guisheng
experimental part, p. 511 - 514 (2012/01/13)
An efficient approach to 1,4-dihydropyridines containing novel substituted pyrazole is achieved via threecomponent reaction of pyrazolyl aldehyde, β-ketoester, and ammonium acetate in one-pot under sulfamic acid catalysis.
Synthesis and biological evaluation of some novel 1,4-dihydropyridines as potential antitubercular agents
Trivedi, Amit,Dodiya, Dipti,Dholariya, Bipin,Kataria, Vipul,Bhuva, Vimal,Shah, Viresh
experimental part, p. 881 - 886 (2012/06/30)
Recent studies showed that 1,4-dihydropyridine-3,5-dicarbamoyl derivatives with lipophilic groups have significant antitubercular activity. In this study, we have synthesized new derivatives of 1,4-dihydropyridines bearing carbmethoxy and carbethoxy group
