438470-19-0

Basic information

• Product Name: METHYL 2-((SUCCINIMIDOOXY)CARBONYL)BENZ&
• Synonyms: Benzoic acid, 2-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]-, Methyl ester;2,5-Dioxopyrrolidin-1-yl methyl phthalate;Methyl 2-[(succinimidooxy)carbonyl]benzoate 97%
• CAS NO: 438470-19-0
• Molecular Formula: C₁₃H₁₁NO₆
• Molecular Weight: 277.231
• Product Categories: C12 to C63;Carbonyl Compounds;Esters
• Mol File: 438470-19-0.mol

Chemical Properties

• Melting Point: 76-80 °C(lit.)
• Boiling Point: 431.2°C at 760 mmHg
• Flash Point: 214.6°C
• Appearance: /
• Density: 1.43g/cm³
• Vapor Pressure: 1.22E-07mmHg at 25°C
• Refractive Index: 1.588
• CAS DataBase Reference: METHYL 2-((SUCCINIMIDOOXY)CARBONYL)BENZ&(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-((SUCCINIMIDOOXY)CARBONYL)BENZ&(438470-19-0)
• EPA Substance Registry System: METHYL 2-((SUCCINIMIDOOXY)CARBONYL)BENZ&(438470-19-0)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 438470-19-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 2-((SUCCINIMIDOOXY)CARBONYL)BENZ& is used as an intermediate in the synthesis of pharmaceuticals for its functional groups and reactivity.
Used in Chemical Industry:
METHYL 2-((SUCCINIMIDOOXY)CARBONYL)BENZ& is used in the synthesis of organic compounds for its functional groups and reactivity.

InChI:InChI=1/C13H11NO6/c1-19-12(17)8-4-2-3-5-9(8)13(18)20-14-10(15)6-7-11(14)16/h2-5H,6-7H2,1H3

Upstream product

• 17592-54-0 2,5-dioxopyrrolidin-1-yl formate 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 4376-18-5 Monomethyl phthalate 

Downstream Products

• 14463-79-7 2-methyl-2-phthalimidopropanoic acid 
• 6306-54-3 N-phthaloyl L-valine 
• 5123-55-7 Nα-phthaloyl-L-phenylalanine 
• 2130-97-4 (S)-N^α-phthaloyl-O-benzyltyrosine 
• 32675-71-1 N-phthalimide-L-tryptophan 
• 1246567-56-5 (S)-2-(2-fluoro-1-phenylethyl)isoindoline-1,3-dione 
• 1452840-69-5 C₁₈H₂₀N₄O₁₀S 
• 1452840-70-8 5'-O-[N-(2-carboxylatobenzoyl)sulfamoyl]cytidine sodium salt 
• 938186-00-6 C₂₇H₂₁ClN₂O₅ 

Relevant articles and documents

Palladium-Catalyzed Carbonylation of (Hetero)Aryl, Alkenyl and Allyl Halides by Means of N-Hydroxysuccinimidyl Formate as CO Surrogate

An efficient Pd-catalyzed carbonylation protocol is described for the coupling of a large panel of aryl, heteroaryl, benzyl, vinyl and allyl halides 2 with the unusual N-hydroxysuccinimidyl (NHS) formate 1 as a CO surrogate to afford the corresponding valuable NHS esters 3. High conversion to the coupling products was achieved with up to 98% yield by means of Pd(OAc)2/Xantphos catalyst system.

Sialyltransferase inhibitors: Consideration of molecular shape and charge/hydrophobic interactions

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Artificial molecular clamp: A novel device for synthetic polymerases

Synthetic polymerases composed of a cyclodextrin (CD) dimer yield high-molecular-weight polymers of cyclic esters without using solvents and co-catalysts. One CD moiety is attached to the active site of a supramolecular catalyst and propagates the polymerization by serving as artificial molecular clamp (see picture). The other CD moiety initiates the ring-opening polymerization. Copyright

Methyl 2-((succinimidooxy)carbonyl)benzoate (MSB): a new, efficient reagent for N-phthaloylation of amino acid and peptide derivatives.

A new, efficient, and readily available reagent, methyl 2-((succinimidooxy)carbonyl)benzoate (MSB), for N-phthaloylation of amino acids and amino acid derivatives is described. The phthaloylation procedure is simple and racemization-free and gives excellent results with alpha-amino acids, alpha-amino alcohols, dipeptides, alpha-amino carboxamides, and alpha-amino esters.