438496-02-7Relevant academic research and scientific papers
New chiral ionic liquids based on imidazolinium salts
Winkel, Andreas,Wilhelm, Rene
experimental part, p. 2344 - 2350 (2010/03/04)
The preparation and application of a new series of chiral ionic liquids are described. The salts are based on imidazolinium cations. Some of the cations also incorporated an axial chirality at the C(2) position next to the central chirality. These cations
A novel general route for the preparation of enantiopure imidazolines.
Boland, Nicola A,Casey, Mike,Hynes, Stephen J,Matthews, Jonathan W,Smyth, Martin P
, p. 3919 - 3922 (2007/10/03)
A novel procedure for the preparation of enantiopure 1,4-disubstituted 2-imidazolines is reported. Enantiopure beta-amino alcohols are converted into N-hydroxyethylamides, which are reacted with excess thionyl chloride, or with thionyl chloride followed by phosphorus pentachloride to yield N-chloroethylimidoyl chlorides. These intermediates are treated with amines and anilines to produce N-chloroethylamidines, which are converted into imidazolines upon workup with aqueous hydroxide. The method is simple and efficient and has been used to prepare a wide variety of enantiopure imidazolines, in a modular fashion, from readily available amino alcohols.
