4385-59-5

Usage

Cyclic lactone

It is a type of lactone with a cyclic structure, which means the carbonyl group (C=O) is part of a ring.

Methyl group

The presence of a -CH3 functional group in the chemical structure of 1-methyl-1,4-dihydro-3H-isochromen-3-one.

Dihydroisochromenone ring system

The compound contains a ring structure consisting of two hydrogen atoms and a carbonyl group, which is derived from the isochromenone structure.

Pharmaceutical industry use

1-methyl-1,4-dihydro-3H-isochromen-3-one is used as a building block for the synthesis of various biologically active molecules.

Antioxidant properties

The compound has the ability to neutralize free radicals, which can help prevent cellular damage and protect against diseases.

Anti-inflammatory properties

It can help reduce inflammation, making it potentially useful in the development of new drugs for treating diseases such as cancer and inflammation.

Flavoring agent

1-methyl-1,4-dihydro-3H-isochromen-3-one is used in the food and beverage industry due to its pleasant aroma and taste.

Upstream product

• 81598-12-1 (2-vinylphenyl)acetic acid 
• 66370-75-0 methyl (2-iodophenyl)acetate 
• 19418-95-2 2-(2-ethylphenyl)acetic acid 
• 36073-90-2 2-(2-acetylphenyl)acetic acid 

Downstream Products

• 95965-79-0 1-methyl-4-(N'-phenylpiperazino)-3-isochromanone 
• 95965-86-9 1-methyl-4-(N'-phenylpiperazino)-3-isochroman 
• 95965-61-0 1-(N,N-dimethylaminomethyl)-3-methyl-1,3-dihydroisobenzofuran 
• 95991-74-5 4-bromo-1-methyl-3-isochromanone 

Relevant academic research and scientific papers

Synthesis of Isoindoles from Intramolecular Condensation of Benzyl Azides with α-Aryldiazoesters

Rh-catalyzed intramolecular condensation of the benzyl azides with α-aryldiazoesters was explored. The reaction proceeded through the nucleophilic attack of the organic azide onto a rhodium carbenoid, while releasing nitrogen gas, affording the α-imino es

Visible-Light-Induced C-O Bond Formation for the Construction of Five- and Six-Membered Cyclic Ethers and Lactones

Visible-light-induced intramolecular C-O bond formation was developed using 2,4,6-triphenylpyrylium tetrafluoroborate (TPT), which allows the regiocontrolled construction of cyclic ethers and lactones. The reaction is likely to proceed through the single-electron oxidation of the phenyl group, followed by the formation of a benzylic radical, thus preventing a competing 1,5-hydrogen abstraction pathway. Detailed mechanistic studies suggest that molecular oxygen is used to trap the radical intermediate to form benzyl alcohol, which undergoes cyclization. This new approach serves as a powerful platform by providing efficient access to valuable five- and six-membered cyclic ethers and lactones with a unified protocol.

Catalytic Synthesis of Saturated Oxygen Heterocycles by Hydrofunctionalization of Unactivated Olefins: Unprotected and Protected Strategies

A mild, general, and functional group tolerant intramolecular hydroalkoxylation and hydroacyloxylation of unactivated olefins using a Co(salen) complex, an N-fluoropyridinium salt, and a disiloxane reagent is described. This reaction was carried out at ro

Synthesis and CNS-activity of spirocyclic pethidine and prodine analogs

The bromoacetals 5a and 5b react with n-butyllithium and the piperidone 7 to yield the hydroxyacetals 8b and 8c, respectively. Cyclization of 8b and 8c followed by acid hydrolysis affords the spirocyclic hemiacetals 10b and 10c which are oxidized by PCC t

Synthesis and Structure-Activity Relationships of 1-Substituted-aminomethyl-3-phenyl/methyl-1,3-dihydroisobenzofurans and 4-Substituted-amino-1-phenyl/methyl-isochromans - A New Class of Antihistaminics

The title compounds have been synthesized from the common intermediates 1-phenyl/methyl-4-bromo-3-isochromanones (10/11) which have been prepared from 2-benzoyl/acetyl-phenylacetic acids (6/7) by NaBH4 reduction followed by bromination of 1-phenyl/methyl-