36073-90-2

Usage

InChI:InChI=1/C10H10O3/c1-7(11)9-5-3-2-4-8(9)6-10(12)13/h2-5H,6H2,1H3,(H,12,13)

Upstream product

• 195871-32-0 2-(2-acetylphenyl)acetaldehyde 
• 83-33-0 inden-1-one 
• 64666-42-8 1-methyl-1-indanol 
• 16535-88-9 (2-acetyk-phenyl)-acetic acid methyl ester 
• 767-60-2 3-Methylindene 

Downstream Products

• 85749-68-4 C₂₂H₂₀O₄ 
• 127998-41-8 (2S,3S,10bR)-3-Hydroxymethyl-10b-methyl-2-phenyl-2,3,6,10b-tetrahydro-oxazolo[2,3-a]isoquinolin-5-one 
• 4385-59-5 1,4-Dihydro-1-methyl-2-benzopyran-3-on 
• 85798-65-8 C₂₂H₂₀O₄ 
• 85749-65-1 C₂₂H₂₀O₄ 
• 85749-69-5 C₂₂H₂₀O₄ 
• 3469-05-4 ethyl 2-(2-acetylphenyl)acetate 
• 26121-51-7 C₂₀H₁₅NO₄ 
• 127998-47-4 (2S,3S,6S,10bR)-6-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-3-hydroxymethyl-6,10b-dimethyl-2-phenyl-2,3,6,10b-tetrahydro-oxazolo[2,3-a]isoquinolin-5-one 
• 128052-79-9 (2S,3S,6R,10bR)-6-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-3-hydroxymethyl-6,10b-dimethyl-2-phenyl-2,3,6,10b-tetrahydro-oxazolo[2,3-a]isoquinolin-5-one 
• 127998-46-3 (2S,3S,6S,10bR)-6-Hex-5-enyl-3-hydroxymethyl-6,10b-dimethyl-2-phenyl-2,3,6,10b-tetrahydro-oxazolo[2,3-a]isoquinolin-5-one 
• 128052-78-8 (2S,3S,6R,10bR)-6-Hex-5-enyl-3-hydroxymethyl-6,10b-dimethyl-2-phenyl-2,3,6,10b-tetrahydro-oxazolo[2,3-a]isoquinolin-5-one 
• 127998-43-0 (2S,3S,6S,10bR)-6-Benzyl-3-hydroxymethyl-6,10b-dimethyl-2-phenyl-2,3,6,10b-tetrahydro-oxazolo[2,3-a]isoquinolin-5-one 
• 128052-75-5 (2S,3S,6R,10bR)-6-Benzyl-3-hydroxymethyl-6,10b-dimethyl-2-phenyl-2,3,6,10b-tetrahydro-oxazolo[2,3-a]isoquinolin-5-one 

Relevant academic research and scientific papers

A novel tandem [2 + 2] cycloaddition-Dieckmann condensation with ynolate anions. Efficient synthesis of substituted cycloalkenones and naphthalenes via formal [n + 1] cycloaddition

A novel tandem [2 + 2] cycloaddition-Dieckmann condensation via ynolate anions is described. Ynolate anions are useful for the formation of reactive β-lactone enolates via a pathway not involving the enolization of the corresponding β-lactones. The [2 + 2] cycloaddition of ynolate anions with δ- or σ-keto esters, followed by Dieckmann condensation, gives bicyclic β-lactones, which are easily decarboxylated to produce synthetically useful 2,3-disubstituted cyclopentenones and cyclohexenones in one pot. This tandem reaction was applied to a novel, one-pot synthesis of highly substituted naphthalenes.

Reactions of carbonyl compounds in basic solutions. Part 21. The mechanisms of the alkaline hydrolysis of substituted methyl 2-(2-oxopropyl)- and 2-(2-oxo-2-phenylethyl)-benzoates and 2-(2-acetylphenyl)- and 2-(2-benzoylphenyl)-acetates

Rate coefficients have been measured for the alkaline hydrolysis of methyl 2-[2-oxo-2-(3- or 4-substituted phenyl)ethyl]benzoates, 2-[2-(3- or 4-substituted benzoyl)phenyl]acetates,2-(2-oxopropyl) and 2-(1,1-dimethyl-2- oxopropyl)benzoates, 2-(2-acetylphenyl)acetate and 2-(2-acetylphenyl)-2,2- dimethylacetates in 70% (v/v) dioxane-water at 30.0 °C. Those for the six parent esters were also measured at 45.0 and 60.0 °C and the enthalpies and entropies of activation have been evaluated. The relative rates of hydrolysis, activation parameters and substituent effects have been used to demonstrate neighbouring participation by the keto-carbonyl groups in the alkaline hydrolysis of the esters under study. For comparable systems, participation by six-membered ring intermediates appears somewhat less advantageous than five-membered.

Asymmetric Synthesis of 4,4-Disubstituted 1-Naphthalenones. Diastereoselectivity as a Function of Metal Oxides

Chiral tricyclic lactam (5) was sequentionally metalated (LDA or LDA/zirconocene halides) and alkylated to give quaternary alkylation products (8) in 6-54:1 diastereomeric ratio.Reduction and hydrolysis furnish the title compound in three steps with >99 p