4385-79-9

Basic information

• Product Name: Pyridine, 4-(4-methoxyphenyl)-2-methyl-
• CAS NO: 4385-79-9
• Molecular Formula: C13H13NO
• Molecular Weight: 199.252
• Mol File: 4385-79-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Pyridine, 4-(4-methoxyphenyl)-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 4-(4-methoxyphenyl)-2-methyl-(4385-79-9)
• EPA Substance Registry System: Pyridine, 4-(4-methoxyphenyl)-2-methyl-(4385-79-9)

Safety Data

• Hazardous Substances Data: 4385-79-9(Hazardous Substances Data)

Upstream product

• 22282-99-1 4-bromo-2-methylpyridine 
• 5720-07-0 4-methoxyphenylboronic acid 
• 5938-16-9 4-(4-methoxylphenyl)pyridine 
• 78782-17-9 4,4,5,5-tetramethyl-2-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]-1,3,2-dioxaborolane 
• 696-62-8 para-iodoanisole 
• 1115492-92-6 2-methyl-4-pyridylzinc bromide 

Relevant articles and documents

Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors

The kinase DYRK1A is an attractive target for drug discovery programs due to its implication in multiple diseases. Through a fragment screen, we identified a simple biaryl compound that is bound to the DYRK1A ATP site with very high efficiency, although with limited selectivity. Structure-guided optimization cycles enabled us to convert this fragment hit into potent and selective DYRK1A inhibitors. Exploiting the structural differences in DYRK1A and its close homologue DYRK2, we were able to fine-tune the selectivity of our inhibitors. Our best compounds potently inhibited DYRK1A in the cell culture and in vivo and demonstrated drug-like properties. The inhibition of DYRK1A in vivo translated into dose-dependent tumor growth inhibition in a model of ovarian carcinoma.

Preparation 2-substituted-4-pyridylzinc bromides via direct insertion of active zinc and their coupling reactions

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