438534-52-2Relevant academic research and scientific papers
A practical radiosynthesis of a tritium-labelled fluorocombretastatin
Hadfield, John A.,Hirst, Nicholas,Gaukroger, Keira,Lawrence, Nicholas J.,McGown, Alan T.
, p. 303 - 306 (2012)
Zybrestat (combretastatin A-4 disodium diphosphate) is currently in clinical trials as an antivascular anticancer agent. A similar fluorinated agent has shown promise as an antivascular agent, and a radiolabelled version would enable further understanding of its biological activities. Herein is described the synthesis of a tritiated fluorinated analogue of Zybrestat. Copyright
