438536-22-2Relevant academic research and scientific papers
Microbial transformation of (+)-nootkatone and the antiproliferative activity of its metabolites
Gliszczyńska, Anna,?ysek, Agnieszka,Janeczko, Tomasz,?witalska, Marta,Wietrzyk, Joanna,Wawrzeńczyk, Czes?aw
experimental part, p. 2464 - 2469 (2011/05/12)
Six metabolites were obtained as a result of microbial transformation of (+)-nootkatone (1) by the fungal strains: Botrytis, Didymosphaeria, Aspergillus, Chaetomium and Fusarium. Their structure were established as (+)-(4R,5S,7R,9R)-9α-hydroxynootkatone (2), (+)-(4R,5S,7R)-13- hydroxynootkatone (3) and (+)-(4R,5S,7R,9R,11S)-11,12-epoxy-9α- hydroxynootkatone (4), (+)-(4R,5S,7R,11S)-11,12-epoksynootkatone (5), (+)-(4R,5S,7R)-11,12-dihydroxynootkatone (6) and (+)-(4R,5S,7R)-7,11,12- trihydroxynootkatone (7) on the basis of their spectral data. Two products: (4) and (7) were not previously reported in the literature. The antiproliferative activity of (+)-nootkatone (1) and isolated metabolites (2-7) of its biotransformation has been evaluated.
