438554-44-0

Usage

Uses

Used in Pharmaceutical Synthesis:
5-nitro-2-(trifluoroMethyl)pyridin-4-ol is utilized as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with targeted therapeutic effects, contributing to advancements in medicinal chemistry.
Used in Agrochemical Synthesis:
In the agrochemical industry, 5-nitro-2-(trifluoroMethyl)pyridin-4-ol is employed as a crucial component in the creation of pesticides and other agrochemicals. Its properties enable the production of effective compounds for crop protection and enhancement of agricultural yields.
Used in Organic Chemistry Research:
5-nitro-2-(trifluoroMethyl)pyridin-4-ol serves as a building block in organic chemistry, allowing researchers to modify its structure to create new derivative compounds with specific functions. This versatility is invaluable for the development of novel materials and compounds with potential applications in various fields.
Used in Antibacterial Applications:
Due to its potential biological activities, 5-nitro-2-(trifluoroMethyl)pyridin-4-ol is studied for its antibacterial properties. It may be used as an active ingredient in the development of new antibiotics to combat resistant bacterial strains.
Used in Antitumor Applications:
5-nitro-2-(trifluoroMethyl)pyridin-4-ol is also being investigated for its antitumor properties, with potential use in the development of anticancer drugs. Its unique structure may contribute to the inhibition of tumor growth and the enhancement of existing cancer treatments.

Upstream product

• 170886-13-2 4-hydroxy-2-trifluoromethylpyridine 
• 657-06-7 2-chloro-5-trifluoromethylbenzoic acid 

Downstream Products

• 438554-45-1 4-chloro-5-nitro-2-(trifluoromethyl)pyridine 
• 438564-37-5 6-(trifluoromethyl)pyridine-3,4-diamine 
• 438564-36-4 5-nitro-2-(trifluoromethyl)pyridin-4-amine 
• 1196153-82-8 5-amino-2-(trifluoromethyl)pyridin-4-ol 

Relevant academic research and scientific papers

FUSED BICYCLIC RAF INHIBITORS AND METHODS FOR USE THEREOF

The present disclosure generally relates to improved synthesis of fused bicyclic Raf inhibitors of formula (I), (I-A), (I-B), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof. The disclosure also relates to method o

ANTIBIOTIC COMPOUNDS

The present invention relates to antibiotic compounds of formula (I), to compositions containing these compounds and to methods of treating bacterial diseases and infections using the compounds. The compounds find application in the treatment of infection with, and diseases caused by, Gram-positive and/or Gram-negative bacteria, and in particular in the treatment of infection with, and diseases caused by, Neisseria gonorrhoeae.

PYRIDO PYRIMIDINONES, DIHYDRO PYRIMIDO PYRIMIDINONES AND PTERIDINONES USEFUL AS RAF KINASE INHIBITORS

The present invention provides compounds having the formula: (I) wherein A-B together represents one of the following structures; (II), (III), (IV) and n, R1, R2, R3, R4, L1, L2, Y and Z are as defined in classes and subclasses herein, and pharmaceutical compositions thereof, as described generally and in subclasses herein, which compounds are useful as inhibitors of protein kinase (e.g., RAF), and thus are useful, for example, for the treatment of RAF mediated diseases.

Benzimidazole and pyridylimidazole derivatives

This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed. This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections.