438622-90-3Relevant academic research and scientific papers
Synthesis of hexa- and octahydropyrido[3′2′:4,5]thieno[3,2-d]pyrimidines
Dotsenko,Krivokolysko,Litvinov
, p. 110 - 112 (2003)
The reaction of N-methylmorpholinium 4-(2-chlorophenyl)-5-cyano-2-oxo-1,2,3,4-tetrahydropyridine-6-thiolate with chloroacetamide in DMF in the presence of an excess of KOH gave 3-amino-2-carbamoyl-4-(2-chlorophenyl)-6-oxo-4,5,6,7-tetrahydrothieno[2, 3-b]pyridine. Refluxing the latter with acyl chlorides in AcOH or heating in formic acid gave hexahydropyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine derivatives and reaction with cyclohexanone gave a spiro-linked octahydropyrido[3′2′:4,5]thieno[3,2-d]pyrimidine.
