438631-77-7

Basic information

• Product Name: (R)-4-N-Boc-piperazine-2-carboxylic acid methyl ester
• Synonyms: (R)-1-N-Boc-piperazine-3-carboxylic acid methyl ester;Methyl (R)-1-N-Boc-piperazine-3-carboxylate;REF DUPL: (R)-4-N-Boc-piperazine-2-carboxylic acid methyl ester;（R)-1-N-Boc-3-piperazinecarboxylic acid methyl ester;Methyl (R)-4-Boc-piperazine-2-carboxylate;(R)-4-N-Boc-piperazine-2-carboxylic acid Methyl ester 96%;R-1-Boc-piperazine-3-carboxylic acid Methyl ester;(R)-4-tert-butyloxypiperazine-2-carboxylic acid Methyl ester
• CAS NO: 438631-77-7
• Molecular Formula: C₁₁H₂₀N₂O₄
• Molecular Weight: 244.289
• Product Categories: Piperaizine
• Mol File: 438631-77-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 321.3 °C at 760 mmHg
• Flash Point: 148.1 °C
• Appearance: /
• Density: 1.118 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 6.45±0.40(Predicted)
• CAS DataBase Reference: (R)-4-N-Boc-piperazine-2-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-N-Boc-piperazine-2-carboxylic acid methyl ester(438631-77-7)
• EPA Substance Registry System: (R)-4-N-Boc-piperazine-2-carboxylic acid methyl ester(438631-77-7)

Safety Data

• Hazardous Substances Data: 438631-77-7(Hazardous Substances Data)

Usage

General Description

"(R)-4-N-Boc-piperazine-2-carboxylic acid methyl ester" is a chemical compound that contains a piperazine ring and a methyl ester functional group. The "R" designation indicates that the molecule is chiral, with the substituents on the carbon atom arranged in a specific orientation. The "N-Boc" group refers to the presence of a tert-butoxycarbonyl (Boc) protecting group attached to the amine nitrogen atom of the piperazine ring. (R)-4-N-Boc-piperazine-2-carboxylic acid methyl ester is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds due to its versatility and reactivity. It is important to handle and store this compound with care, as it may pose hazards if mishandled.

Upstream product

• 67-56-1 methanol 
• 173774-48-6 (R)-piperazine-1,2,4-tricarboxylic acid 1,4-di-tert-butyl ester 

Downstream Products

• 954369-31-4 (R)-1-(4-chloro-benzyl)-piperazine-2-carboxylic acid methyl ester 
• 954369-36-9 (R)-1-(4-chlorophenyl)-piperazine-2-carboxylic acid methyl ester 

Relevant articles and documents

Method for synthesizing monoamine-protected piperazine-(R/S)2-formate

The invention discloses a method for synthesizing monoamine-protected piperazine-(R/S)2-formate, wherein the method comprises the steps: by using 2-piperazinecarboxylate as a raw material, protecting1,4-site amines by using different protective groups, and salifying by using different chiral amines, resolving to obtain a single chiral compound; and finally, using pyridine or DMAP and other pyridine analogues as an alkali, reacting oxalyl chloride, triphosgene, phosgene, thionyl chloride and other similar acyl chlorides in anhydrous tetrahydrofuran, 2-methyl tetrahydrofuran or toluene and other solvents, and finally adding methanol, ethanol, isopropanol, benzyl alcohol and other alcohol reagents to generate the target product capable of removing carboxylic acid ortho-amino protecting groups in a positioned manner and esterifying carboxylic acid. Amino groups on piperazine are separately protected through simple three-step reaction, chiral resolution is performed by utilizing the characteristics of acid, finally, protonated intermediates are formed through organic alkali and carboxylic acid, anhydride is formed by the protonated intermediates and ortho-amino groups, formic acid esterification is performed by utilizing alcohol to replace ring opening, and a final product is obtained.