4388-57-2

Basic information

• Product Name: 2-Methyl-1,3-dioxolane-2-propanoic Acid
• Synonyms: 2-Methyl-1,3-dioxolane-2-propanoic Acid;3-(2-Methyl-1,3-dioxolan-2-yl)propanoic Acid;4-Oxo-pentanoic Acid Cyclic 1,2-Ethanediyl Acetal;Levulinic Acid Cyclic Ethylene Acetal
• CAS NO: 4388-57-2
• Molecular Formula: C₇H₁₂O₄
• Molecular Weight: 160.17
• Product Categories: All Aliphatics;Aliphatics;Heterocycles
• Mol File: 4388-57-2.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 243.3±25.0 °C(Predicted)
• Appearance: /
• Density: 1.161±0.06 g/cm3(Predicted)
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 4.71±0.10(Predicted)
• CAS DataBase Reference: 2-Methyl-1,3-dioxolane-2-propanoic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-1,3-dioxolane-2-propanoic Acid(4388-57-2)
• EPA Substance Registry System: 2-Methyl-1,3-dioxolane-2-propanoic Acid(4388-57-2)

Safety Data

• Hazardous Substances Data: 4388-57-2(Hazardous Substances Data)

Usage

Chemical Properties

Colourless Oil

Uses

2-Methyl-1,3-dioxolane-2-propanoic Acid (cas# 4388-57-2) is a compound useful in organic synthesis.

Upstream product

• 35351-33-8 methyl 3‐(2‐methyl‐1,3‐dioxolan‐2‐yl)propanoate 
• 624-45-3 levulinic acid methyl ester 
• 539-88-8 4-oxopentanoic acid ethyl ester 
• 107-21-1 ethylene glycol 
• 123-76-2 levulinic acid 
• 24108-29-0 3-(2-methyl-[1,3]dioxolan-2-yl)-propionaldehyde 
• 126-39-6 2-ethyl-2-methyl-1,3-dioxolane 
• 62603-41-2 β-hydroxyethyl 2-methyl-1,3-dioxolane-2-propionate 
• 1115-30-6 diethyl acetylsuccinate 
• 143674-66-2 Potassium; 3-(2-methyl-[1,3]dioxolan-2-yl)-propionate 
• 941-43-5 Ethyl levulinate ethylene ketal 

Downstream Products

• 29021-98-5 3-(2-methyl-[1,3]dioxolan-2-yl)-propan-1-ol 
• 4868-21-7 undec-8c-ene-2,5-dione 
• 110-13-4 2,5-hexanedione 
• 1253176-60-1 1-((2R,3R)-1-(bis(4-methoxy-3,5-dimethyl-phenyl)methyl)-3-phenylaziridin-2-yl)-3-(2-methyl-1,3-dioxolan-2-yl)propan-1-one 
• 1253176-61-2 1-((2R,3R)-1-(bis(4-methoxy-3,5-dimethyl-phenyl)methyl)-3-cyclohexylaziridin-2-yl)-3-(2-methyl-1,3-dioxolan-2-yl)propan-1-one 
• 1253176-45-2 1-((2S,3S)-1-(bis(4-methoxy-3,5-dimethyl-phenyl)methyl)-3-phenylaziridin-2-yl)-3-(2-methyl-1,3-dioxolan-2-yl)propan-1-one 
• 1253176-46-3 1-((2S,3S)-1-(bis(4-methoxy-3,5-dimethyl-phenyl)methyl)-3-cyclohexylaziridin-2-yl)-3-(2-methyl-1,3-dioxolan-2-yl)propan-1-one 
• 1092964-78-7 (2R,4S,5R)-4-(but-3-en-1-yl)-2-phenyl-1,3-dioxan-5-yl 3-(2-methyl-1,3-dioxolan-2-yl)propanoate 
• 85877-58-3 3-Hydroxy-2-(2-methyl-[1,3]dioxolan-2-ylmethyl)-3-phenyl-butyric acid 
• 85877-59-4 5-Ethyl-hept-4-en-2-one 
• 35351-33-8 methyl 3‐(2‐methyl‐1,3‐dioxolan‐2‐yl)propanoate 
• 1128-08-1 dihydro-cis-jasmone 
• 7018-92-0 2,5-Undecanedione 
• 3214-41-3 octane-2,5-dione 

Relevant articles and documents

Acid Catalyzed Competitive Esterification and Ketalization of Levulinic Acid with 1,2 and 1,3-Diols: The Effect of Heterogeneous and Homogeneous Catalysts

Abstract: Condensation reactions of levulinic acid (LA) with 1,2-ethanediol (1,2-ED), 1,2-propanediol (1,2-PD), and 1,3-propanediol (1,3-PD) were studied using Amberlyst-15 as well as p-toluenesulfonic acid catalysts in benzene under Dean–Stark conditions. In Amberlyst-15 catalyzed reactions the products are ketals and ketal-esters, whereas p-toluenesulfonic acid catalyzed reactions produce esters and ketal-esters as products. In p-toluenesulfonic acid catalyzed reactions with 1,2-ED and 1,3-PD, LA monoester product is formed as the major product after 180?min in 75 and 97?% yields respectively. Unlike the previously reported acid catalyzed ketalization of ethyl levulinate with diols, combined ketalization–esterification of LA with diols is a complex process. Graphical Abstract: [Figure not available: see fulltext.]

SUBSTITUTED FUSED[1,2]IMIDAZO[4,5-C] RING COMPOUNDS AND METHODS

[1,2]Imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and imidazo[4,5-c]pyridines) substituted with a fused ring containing an oxygen and/or nitrogen atom attached at the 1- and/or 2-position, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

Total synthesis of Cacalol

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