439081-07-9

Usage

Uses

Used in Pharmaceutical Research:
Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-2'-O-[2-[(trifluoroacetyl)amino]ethyl]is used as a research compound for studying the effects of modified nucleosides on various biological processes. The additional chemical groups in this derivative may provide unique insights into the interactions between nucleosides and other biomolecules, as well as their potential therapeutic applications.
Used in Drug Development:
This modified uridine derivative may be used in the development of new drugs targeting specific diseases or conditions. The unique chemical structure of Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-2'-O-[2-[(trifluoroacet yl)amino]ethyl]- could potentially enhance its binding affinity to target proteins or enzymes, leading to improved therapeutic efficacy.
Used in Diagnostic Applications:
Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-2'-O-[2-[(trifluoroacetyl)amino]ethyl]may also be used in the development of diagnostic tools, such as imaging agents or biosensors, that rely on the specific interactions between nucleosides and other biomolecules.
Used in Biochemical Studies:
This modified uridine derivative can be employed in biochemical studies to investigate the role of nucleosides in various cellular processes, such as DNA replication, RNA synthesis, and protein synthesis. The additional chemical groups in Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-2'-O-[2-[(trifluoroacet yl)amino]ethyl]- may provide valuable information on the mechanisms of these processes and their regulation.

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 911110-78-6 [2'-O-(2-trifluoroacetamido)ethyl-β-D-ribofuranosyl]thymine 
• 200423-87-6 Toluene-4-sulfonic acid 2-[(2R,3R,3aR,9aR)-2-(3-benzyloxymethyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yloxy]-ethyl ester 
• 200423-85-4 [(2R,3R,3aR,9aR)-2-(3-Benzyloxymethyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yloxy]-acetic acid methyl ester 
• 210116-33-9 2,2,2-Trifluoro-N-{2-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yloxy]-ethyl}-acetamide 
• 200423-86-5 2'-O-(2-hydroxyethyl)-3',5'-O-tetraisopropyl-di-siloxyl-N³-benzyloxymethyl-5-methyl uridine 
• 210116-32-8 1-[(2R,3R,3aR,9aR)-3-(2-Azido-ethoxy)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 65-71-4 thymin 
• 911110-76-4 [3',5'-di-O-acetyl-2'-O-(2-trifluoroacetamido)ethyl-β-D-ribofuranosyl]thymine 
• 676168-51-7 1,3,5-tri-O-acetyl-2-O-(2-trifluoroacetamido)ethyl-D-ribofuranoside 

Relevant academic research and scientific papers

2′-O-aminoethyl oligoribonucleotides containing novel base analogues: Synthesis and triple-helix formation at pyrimidine/purine inversion sites

The synthesis of a common sugar intermediate for the 2′-aminoethyl- ribonucleoside synthesis in 9 steps and an overall yield of 33 % starting from D-ribose is described. This intermediate was successfully used for the synthesis of the 2′-aminoethyl-ribonucleosides containing the bases thymine (t), 5-methylcytosine (c), 5-methyl-2-pyrimidinone (x), 2-aminopurine (ap) and guanine (g). These were subsequently transformed into the corresponding cyanoethyl phosphoramidite building blocks for oligonucleotide synthesis. 2′-Aminoethyl oligonucleotide 15-mers were prepared with a DNA synthesizer, and an optimized post-synthetic deprotection protocol has been developed which prevents cyanoethylation of the 2′-amino side chains during conventional ammonia deprotection. A series of fully modified, triplex forming 2′-aminoethyl oligoribonucleotides (2′AE-TFOs) were prepared in which x was designed to bind to CG inversion sites and ap as well as g to TA inversion sites on a double-helical DNA target. The affinity of x-CG base-triple formation in different sequence contexts was assessed by UV- and CD melting analysis. It was found that TFO 15-mers containing up to 5 x residues still form stable triplexes even in the case where all x residues are consecutively arranged in the TFO. The nearest neighbor properties of x have been probed and it was found that triplex stability decreases in the local sequence order -txt- > -txc- ? -cxc-. TFOs containing ap and g were found to bind to their DNA targets with TA inversion sites with less affinity and less selectivity compared to TFOs containing the corresponding deoxyribonucleosides, irrespective whether they were incorporated in TFOs with a DNA or a 2′-AE-RNA backbone. The obtained data suggest that guanine-TA or aminopurine-TA base-triple formation is strongly sensitive to TFO conformation and more efficient in TFOs with a DNA than an RNA backbone. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.

Dual recognition of double-stranded DNA by 2'-aminoethoxy-modified oligonucleotides

Simultaneous interaction of the 2'-aminoethoxy-modified oligonucleotides with the phosphodiester backbone (shown on the right, A) and with the bases through Hoogsteen base contacts (B) is seen at each base-pair step of the duplex DNA target. The electrost