439084-74-9Relevant academic research and scientific papers
Synthesis and characterization of 4,6-dichloroindole-based radioligands for imaging the glycine site of the NMDA ion channel
Waterhouse,Sultana,Guo,Lee, Bora,Simpson,Collier, Lee,Laruelle
, p. 91 - 102 (2007/10/03)
To provide effective PET or SPECT ligands for the glycine binding site of the NMDA ion channel, we have synthesized and characterized in vitro four substituted derivatives of the potent glycine site antagonist 3-[2-[(phenylamino)carbonyl]ethenyl]-4,6-dich
Substituted indole-2-carboxylates as in vivo potent antagonists acting as the strychnine-insensitive glycine binding site
Di Fabio, Romano,Capelli, Anna M.,Conti, Nadia,Cugola, Alfredo,Donati, Daniele,Feriani, Aldo,Gastaldi, Paola,Gaviraghi, Giovanni,Hewkin, Cheryl T.,Micheli, Fabrizio,Missio, Andrea,Mugnaini, Manolo,Pecunioso, Angelo,Quaglia, Anna M.,Ratti, Emiliangelo,Rossi, Luciana,Tedesco, Giovanna,Trist, David G.,Reggiani, Angelo
, p. 841 - 850 (2007/10/03)
A series of indole-2-carboxylates bearing suitable chains at the C-3 position of the indole nucleus was synthesized and evaluated in terms of in vitro affinity using [3H]glycine binding assay and in vivo potency by inhibition of convulsions ind
