439120-99-7Relevant academic research and scientific papers
Solid-phase synthesis of disubstituted 1,3-dihydro-2H-imidazol-2-ones
Patek,Weichsel,Drake,Smrcina
, p. 1322 - 1324 (2007/10/03)
An efficient and straightforward solid-phase synthesis of sulfonylimidazolones 2a-g is described. Our design was directed toward obtaining molecules for a general library development and incorporates functionalities that fulfill lead-like criteria. The synthesis was realized with the use of SPOS in fair to good yields and purity. Monitoring and quantitation of intermediates and final products were performed by the use of LCMS and NMR spectroscopy.
The reaction of 1,2-diones with ureas - A synthesis of 4-(1-substituted)alkylimidazol-2-ones
Liepa, Andris J.,Wright, Denis M.J.
, p. 73 - 76 (2007/10/03)
The reaction between glyoxal and ureas or thioureas in formic acid in the presence of sulfmates gives 4-arylsulfonylimidazol-2-ones such as (3b) and (3e). Labile 4-arylsulfonyl-5-hydroxyimidazolidin-2-ones (2a-c) may be isolated. Acyclic or cyclic 1,2-diketones react with ureas in the presence of selected nucleophiles to give side-chain substituted imidazol-2-ones (5a-e). CSIRO 2000.
Generality and scope of the synthesis of 2-arylpyrrolo[3,4-b] quinoxaline-1,3-diones from 2,3-dichloro-N-arylmaleimides. II
Hanaineh-Abdelnour, Leila,Salameh, Badr A.
, p. 2931 - 2940 (2007/10/03)
Nucleophilic substitution of 2,3-dichloro-N-arylmaleimides (1) and (2) with a series of arylamines gives 2-arylamino-3-chloro-N-arylmaleimides (3) and (4), respectively. When 4 is treated with sodium azide at room temperature, it cyclizes to the 2-(p-methoxyphenyl)pyrrolo[3,4-b]quinoxaline- 1,3-diones (5). Under the same conditions, the 2-(p-nitrophenyl) analogue (3) fails to cyclize. Ring closure is also subject to the steric and electronic effects of substituents in the nucleophile.
