439265-03-9

Upstream product

• 5029-66-3 methyl 3-iodopropanoate 
• 439265-02-8 Trifluoro-methanesulfonic acid (2R,4aR,9aS)-2-phenyl-4a,8,9,9a-tetrahydro-4H-1,3,5-trioxa-benzocyclohepten-6-yl ester 
• 250226-97-2 (2R,4aR,9aS)-2-Phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-6-one 

Downstream Products

• 439264-70-7 (2R,4aR,5aS,9aR,11aS)-2-Phenyl-octahydro-1,3,5,9-tetraoxa-dibenzo[a,d]cyclohepten-8-one 
• 439264-78-5 (2R,4aR,6S,7R,9aS)-6-(3-Hydroxy-propyl)-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-7-ol 

Relevant academic research and scientific papers

Synthesis of the E ring segment of ciguatoxin CTX3C via the negishi coupling of cyclic ketene acetal triflates

Stereocontrolled synthesis of the E ring segment of ciguatoxin CTX3C was performed via the Negishi coupling of cyclic ketene acetal triflates. Transformation of 8-membered lactones to the corresponding ketene acetal triflates was found to be affected by the protective groups of the substrates.

Concise synthesis of cyclic ethers via the palladium-catalyzed coupling of ketene acetal triflates and organozinc reagents. Application to the iterative synthesis of polycyclic ethers

The reaction of the ketene acetal triflates 9a-e and a zinc homoenolate 10 in the presence of a catalytic amount of Pd(PPh3)4 gave the enol ethers 11a-e in good yields. The products were converted to the corresponding cyclic ethers 1

Concise synthesis of cyclic ethers via the palladium-catalyzed coupling of ketene acetal triflates and a zinc homoenolate. Synthesis of the DE and GH ring segments of gambierol

Concise syntheses of the DE and GH ring segments of gambierol (1) were achieved by the palladium-catalyzed coupling of ketene acetal triflates and a zinc homoenolate, followed by the hydroboration of the resulting cyclic enol ethers and subsequent lactoni