439277-53-9Relevant academic research and scientific papers
An Exceedingly Mild, Green Synthesis of Substituted N-3-diaryl-1,8-naphthyridin-2-amine Derivatives and Their Antimicrobial Activity
Ravi, Dharavath,Rambabu, Sirgamalla,Ashok, Kommakula,Madhu, Palithapu,Sakram, Boda
, p. 957 - 963 (2018)
An exceedingly and highly efficient procedure has been described for the synthesis of substituted N-3-diaryl-1,8-naphthyridin-2-amines by the reaction of 2-chloro-3-aryl-1,8-naphthyridines with various anilines in the presence of N-methyl-2-pyrrolidone and K2CO3 under thermal green solvent-free conditions. The significant features of this green reaction include very good yields in purity, simple experimental, short reaction time, easy workability, and avoidance of toxic solvents. All synthesized compounds have been evaluated for their antibacterial activity.
An Efficient Microwave-Assisted Synthesis of Novel 2-{4-[(3-Aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoline-1,3(2H)-diones and Their Antimicrobial Activity
Sakram,Ravi,Ashok,Rambabu,Sonyanaik,Kurumanna
, p. 780 - 788 (2018/06/14)
The Buchwald–Hartwig amination reaction between 2-chloro-3-aryl-1,8-naphthyridines and 2-(4-aminophenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione in the presence of the catalytic system Pd(PPh3)4 and the base KO-t-Bu in toluene was studied. The reaction was initiated by microwave irradiation. Highly efficient synthesis has been developed for 2-{4-[(3-aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoline-1,3(2H)-diones. Structures of the synthesized compounds were evaluated by IR, 1H and 13C NMR spectroscopy. All products were tested for antimicrobial activity against Escheria coli, Bacillus subtilis, Klebsiella pneumoniae, and Staphylococcus aureus.
Hypervalent iodine mediated synthesis of 1,2,4-triazolo [4,3-a] [1,8]naphthyridines
Mogilaiah,Srinivasa Chowdary
, p. 1894 - 1898 (2007/10/03)
2-Aminonicotinaldehyde 1 on condensation with p-chlorophenylacetonitrile 2 affords 2-amino-3-(p-chlorophenyl)-1,8-naphthyridine 3, which is converted into 2-hydrazino-3-(p-chlorophenyl)-1,8-naphthyridine 4 by the reaction with hydrazine hydrate and conc.
