439277-53-9Relevant articles and documents
An Exceedingly Mild, Green Synthesis of Substituted N-3-diaryl-1,8-naphthyridin-2-amine Derivatives and Their Antimicrobial Activity
Ravi, Dharavath,Rambabu, Sirgamalla,Ashok, Kommakula,Madhu, Palithapu,Sakram, Boda
, p. 957 - 963 (2018)
An exceedingly and highly efficient procedure has been described for the synthesis of substituted N-3-diaryl-1,8-naphthyridin-2-amines by the reaction of 2-chloro-3-aryl-1,8-naphthyridines with various anilines in the presence of N-methyl-2-pyrrolidone and K2CO3 under thermal green solvent-free conditions. The significant features of this green reaction include very good yields in purity, simple experimental, short reaction time, easy workability, and avoidance of toxic solvents. All synthesized compounds have been evaluated for their antibacterial activity.
Hypervalent iodine mediated synthesis of 1,2,4-triazolo [4,3-a] [1,8]naphthyridines
Mogilaiah,Srinivasa Chowdary
, p. 1894 - 1898 (2007/10/03)
2-Aminonicotinaldehyde 1 on condensation with p-chlorophenylacetonitrile 2 affords 2-amino-3-(p-chlorophenyl)-1,8-naphthyridine 3, which is converted into 2-hydrazino-3-(p-chlorophenyl)-1,8-naphthyridine 4 by the reaction with hydrazine hydrate and conc.