439277-55-1

Basic information

• Product Name: 2-chloro-3-(4-chlorophenyl)-1,8-naphthyridine
• Synonyms: 2-chloro-3-(4-chlorophenyl)-1,8-naphthyridine
• CAS NO: 439277-55-1
• Molecular Weight: 275.137
• Mol File: 439277-55-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-chloro-3-(4-chlorophenyl)-1,8-naphthyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-3-(4-chlorophenyl)-1,8-naphthyridine(439277-55-1)
• EPA Substance Registry System: 2-chloro-3-(4-chlorophenyl)-1,8-naphthyridine(439277-55-1)

Safety Data

• Hazardous Substances Data: 439277-55-1(Hazardous Substances Data)

Upstream product

• 140-53-4 p-chlorobenzyl cyanide 
• 7521-41-7 2-Aminonicotinaldehyde 
• 439277-53-9 2-amino-3-(4-chlorophenyl)-1,8-naphthyridine 
• 439277-54-0 1,2-dihydro-3-(4-chlorophenyl)-2H-[1,8]-naphthyridin-2-one 

Downstream Products

• 1226871-15-3 2-(4-acetylphenylamino)-3-(4-chlorophenyl)-1,8-naphthyridine 
• 1075254-10-2 C₂₀H₁₁ClN₄O 

Relevant articles and documents

Microwave assisted synthesis of imidazo[1,2-a][1,8]Naphthyridin-1(2H)-ones

Synthesis of 2-carboxyalkylamino-3-(p-chlorophenyl)-1,8-naphthyridines and their conversion into novel imidazo [1,2-a][1,8]naphthyridin-1(2H)-ones under microwave irradiation are described.

An Efficient Microwave-Assisted Synthesis of Novel 2-{4-[(3-Aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoline-1,3(2H)-diones and Their Antimicrobial Activity

The Buchwald–Hartwig amination reaction between 2-chloro-3-aryl-1,8-naphthyridines and 2-(4-aminophenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione in the presence of the catalytic system Pd(PPh3)4 and the base KO-t-Bu in toluene was studied. The reaction was initiated by microwave irradiation. Highly efficient synthesis has been developed for 2-{4-[(3-aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoline-1,3(2H)-diones. Structures of the synthesized compounds were evaluated by IR, 1H and 13C NMR spectroscopy. All products were tested for antimicrobial activity against Escheria coli, Bacillus subtilis, Klebsiella pneumoniae, and Staphylococcus aureus.