439292-93-0

Upstream product

• 870-46-2 t-butoxycarbonylhydrazine 
• 65632-62-4 (3S)-hexahydro-1,3-pridazinedicarboxylic acid 1-(phenylmethyl) ester 
• 439292-92-9 3-(N'-tert-butoxycarbonyl-hydrazinocarbonyl)-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester 

Downstream Products

• 439292-95-2 3-(N'-tert-butoxycarbonyl-hydrazinocarbonyl)-2-{2-[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-4-methyl-pentanoyl}-tetrahydro-pyridazine-1-carboxylic acid benzyl ester 
• 439292-91-8 3-(N'-tert-butoxycarbonyl-hydrazinocarbonyl)-2-(4-methyl-2-methylamino-pentanoyl)-tetrahydro-pyridazine-1-carboxylic acid benzyl ester 
• 439292-97-4 (S)-2-[(R)-2-({(S)-2-[Benzyloxy-((R)-1-benzyloxycarbonyl-hexahydro-pyridazine-3-carbonyl)-amino]-propionyl}-methyl-amino)-4-methyl-pentanoyl]-3-(N'-tert-butoxycarbonyl-hydrazinocarbonyl)-tetrahydro-pyridazine-1-carboxylic acid benzyl ester 
• 439292-96-3 C₆₃H₇₄N₈O₁₃ 
• 201666-99-1 (S)-3-(N'-tert-Butoxycarbonyl-hydrazinocarbonyl)-2-{(R)-2-[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionyl}-tetrahydro-pyridazine-1-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Total synthesis of (+)-azinothricin and (+)-kettapeptin

(Chemical Equation Presented) Asymmetric total syntheses of (+)-azinothricin and (+)-kettapeptin have been completed through a common new pathway that exploits a highly chemoselective coupling reaction between the fully elaborated cyclodepsipeptide 5 and the glycal activated esters 3 and 4 at the final stages of both respective syntheses.

Synthetic route to the GE3 cyclodepsipeptide.

[reaction: see text] A reasonably efficient [2 + 2 + 2] fragment condensation strategy has been developed for assembling the cyclodepsipeptide sector of GE3 that involves 5-7. A Carpino HATU-mediated macrolactamization was used to close the 19-membered cy