Welcome to LookChem.com Sign In|Join Free

CAS

  • or

86060-87-9

Post Buying Request

86060-87-9 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

86060-87-9 Usage

General Description

FMOC-VAL-OPFP is a chemical compound consisting of FMOC (9-fluorenylmethyloxycarbonyl) and OPFP (2,4-dinitrophenyl) protecting groups attached to the amino acid valine. FMOC-VAL-OPFP is used in peptide synthesis as a protecting group, which prevents unwanted reactions with other functional groups during the synthetic process. The FMOC group is often used at the N-terminal of the peptide sequence, while the OPFP group is utilized to protect the side chain of the valine residue. FMOC-VAL-OPFP is commonly employed in solid-phase peptide synthesis for the production of complex peptides and protein fragments used in drug development, biochemical research, and medical diagnostics.

Check Digit Verification of cas no

The CAS Registry Mumber 86060-87-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,0,6 and 0 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 86060-87:
(7*8)+(6*6)+(5*0)+(4*6)+(3*0)+(2*8)+(1*7)=139
139 % 10 = 9
So 86060-87-9 is a valid CAS Registry Number.
InChI:InChI=1/C26H20F5NO4/c1-12(2)23(25(33)36-24-21(30)19(28)18(27)20(29)22(24)31)32-26(34)35-11-17-15-9-5-3-7-13(15)14-8-4-6-10-16(14)17/h3-10,12,17,23H,11H2,1-2H3,(H,32,34)/t23-/m0/s1

86060-87-9 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (H66818)  N-Fmoc-L-valine pentafluorophenyl ester, 98%   

  • 86060-87-9

  • 1g

  • 294.0CNY

  • Detail
  • Alfa Aesar

  • (H66818)  N-Fmoc-L-valine pentafluorophenyl ester, 98%   

  • 86060-87-9

  • 5g

  • 1176.0CNY

  • Detail
  • Aldrich

  • (47507)  Fmoc-Val-OPfp  ≥98.0% (HPLC)

  • 86060-87-9

  • 47507-1G-F

  • 396.63CNY

  • Detail

86060-87-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name (2,3,4,5,6-pentafluorophenyl) (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methylbutanoate

1.2 Other means of identification

Product number -
Other names Pentafluorophenyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valinate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:86060-87-9 SDS

86060-87-9Relevant articles and documents

Total Chemical Synthesis and Folding of All- l and All- d Variants of Oncogenic KRas(G12V)

Levinson, Adam M.,McGee, John H.,Roberts, Andrew G.,Creech, Gardner S.,Wang, Ting,Peterson, Michael T.,Hendrickson, Ronald C.,Verdine, Gregory L.,Danishefsky, Samuel J.

supporting information, p. 7632 - 7639 (2017/06/13)

The Ras proteins are essential GTPases involved in the regulation of cell proliferation and survival. Mutated oncogenic forms of Ras alter effector binding and innate GTPase activity, leading to deregulation of downstream signal transduction. Mutated forms of Ras are involved in approximately 30% of human cancers. Despite decades of effort to develop direct Ras inhibitors, Ras has long been considered "undruggable" due to its high affinity for GTP and its lack of hydrophobic binding pockets. Herein, we report a total chemical synthesis of all-l- and all-d-amino acid biotinylated variants of oncogenic mutant KRas(G12V). The protein is synthesized using Fmoc-based solid-phase peptide synthesis and assembled using combined native chemical ligation and isonitrile-mediated activation strategies. We demonstrate that both KRas(G12V) enantiomers can successfully fold and bind nucleotide substrates and binding partners with observable enantiodiscrimination. By demonstrating the functional competency of a mirror-image form of KRas bound to its corresponding enantiomeric nucleotide triphosphate, this study sets the stage for further biochemical studies with this material. In particular, this protein will enable mirror-image yeast surface display experiments to identify all-d peptide ligands for oncogenic KRas, providing a useful tool in the search for new therapeutics against this challenging disease target.

Synthesis of aryl esters of protected amino acids from aryl sulfonates

Pudhom, Khanitha,Vilaivan, Tirayut

, p. 5939 - 5942 (2007/10/03)

Aryl esters of Boc- and Fmoc-protected amino acids derived from electron-deficient phenols have been prepared in good yields from aryl 4- nitrobenzenesulfonates in the presence of 1-hydroxy-benzotriazole as catalyst.

9-Fluorenylmethyl Pentafluorophenyl Carbonate as a Useful Reagent for the Preparation of N-9-Fluorenylmethyloxycarbonylamino Acids and their Pentafluorophenyl Esters

Schoen, Istvan,Kisfaludy, Lajos

, p. 303 - 305 (2007/10/02)

9-Fluorenylmethyl pentafluorophenyl carbonate is a useful reagent for the efficient, side reaction-free introduction of N-9-fluorenylmethyloxycarbonyl protecting group into amino acids and for the subsequent preparation of their pentafluorophenyl esters.Some new compounds of both types are described.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 86060-87-9