439660-78-3

Basic information

• Product Name: 2-[1-(3,4-dimethoxy-phenyl)-methanoyl]-cyclohexanecarboxylic acid
• Synonyms: 2-[1-(3,4-dimethoxy-phenyl)-methanoyl]-cyclohexanecarboxylic acid
• CAS NO: 439660-78-3
• Molecular Weight: 292.332
• Mol File: 439660-78-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-[1-(3,4-dimethoxy-phenyl)-methanoyl]-cyclohexanecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[1-(3,4-dimethoxy-phenyl)-methanoyl]-cyclohexanecarboxylic acid(439660-78-3)
• EPA Substance Registry System: 2-[1-(3,4-dimethoxy-phenyl)-methanoyl]-cyclohexanecarboxylic acid(439660-78-3)

Safety Data

• Hazardous Substances Data: 439660-78-3(Hazardous Substances Data)

Upstream product

• 91-16-7 1,2-dimethoxybenzene 
• 85-42-7 1,2-Cyclohexanedicarboxylic acid-anhydride 

Downstream Products

• 1361398-68-6 2-(2-bromopentyl)-4-(3,4-dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydrophthalazin-1(2H)-one 
• 1361398-79-9 N-(5-(2-((2-(4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl)butyl)amino)-1-hydroxyethyl)-2-hydroxyphenyl)formamide 
• 1361398-80-2 N-(5-(2-((2-(4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl)pentyl)amino)-1-hydroxyethyl)-2-hydroxyphenyl)formamide 
• 1361398-81-3 N-(5-(2-((2-(4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl)hexyl)amino)-1-hydroxyethyl)-2-hydroxyphenyl)formamide 
• 1361398-82-4 N-(5-(2-((2-(4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl)butyl)amino)-1-hydroxyethyl)-2-hydroxyphenyl)formamide 
• 1361398-83-5 N-(5-(2-((2-(4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydrophthalazin-2(1H)-yl)butyl)amino)-1-hydroxyethyl)-2-hydroxyphenyl)formamide 
• 380227-28-1 4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one 
• 1361398-66-4 2-(2-bromoethyl)-4-(3,4-dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydrophthalazin-1(2H)-one 
• 357980-82-6 4-(3,4-dimethoxy-phenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one 
• 1116690-31-3 2-(2-bromopentyl)-4-(3,4-dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydrophthalazin-1(2H)-one 

Relevant articles and documents

Design, synthesis and evaluation of dual pharmacology β2- adrenoceptor agonists and PDE4 inhibitors

A novel series of formoterol-phthalazinone hybrids were synthesised and evaluated as dual pharmacology β2-adrenoceptor agonists and PDE4 inhibitors. Most of the hybrids displayed high β2-adrenoceptor agonist and moderate PDE4 inhibitory activities. The most potent compound, (R,R)-11c, exhibited agonist (EC50 = 1.05 nM, pEC50 = 9.0) and potent PDE4B2 inhibitory activities (IC50 = 0.092 μM).

Phthalazinones

PCT No. PCT/EP98/00124 Sec. 371 Date Jul. 14, 1999 Sec. 102(e) Date Jul. 14, 1999 PCT Filed Jan. 12, 1998 PCT Pub. No. WO98/31674 PCT Pub. Date Jul. 23, 1998Compounds of formula I wherein R1, R2, R3, R4 and R5 have the means set forth in the description are selective cyclic nucleotide phosphodiesterase (PDE) inhibitors (specifically of type 4), which are effective bronchial therapeutics.